Clinical Chemistry – Tumour Markers as Diagnostic Tests for Cancer 2018/12/06 LaboTube Channel
Author Archives: scienceandtechnology.jp
肝臓がんについて
肝臓がんの概観
Liver Cancer | Advancements in Treatment Options 2017/06/05 Johns Hopkins Medicine
治療方法について
肝臓がんの治療方法は多様であり、がんの状態に合わせて選択されるそうです。下の動画では、UCLAの放射線医が、インターベンショナルラジオロジー(Interventional Radiology; IVR)による治療として、Thermal ablation(Radiofrequencey Ablation (RFA)経皮的ラジオ波焼灼療法), Microwave Ablation (MWA))、 Transarterial chemoembolization (TACE)、 Transarterial Y90 Radioembolizationの3つの方法を紹介しています。
Minimally Invasive Treatment for Liver Cancer – Sid Padia, MD | UCLAMDCHAT 2017/10/17 UCLA Health
IPILIMUMABの臨床試験(NIH ClinicalTrials.govデータベースの検索結果)
IPILIMUMAB(MDX-010)で臨床試験のデータベースNIH ClinicalTrials.govを検索した結果です(2019年11月3日検索)
- Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery (Phase 1) NCT00025181
- Novel Adjuvants for Peptide-Based Melanoma Vaccines (Phase 1) NCT00028431
- Vaccine Therapy and Monoclonal Antibody Therapy in Treating Patients With Stage IV Melanoma (Phase 2) NCT00032045
- Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer (Phase 1) NCT00039091
- Monoclonal Antibody Therapy in Treating Patients With Lymphoma or Colon Cancer That Has Not Responded to Vaccine Therapy (Phase 1) NCT00047164
- Comparison Study of MDX-010 (CTLA-4) Alone and Combined With DTIC in the Treatment of Metastatic Melanoma (Phase 2) NCT00050102
- Comparison Study of MDX-010 (CTLA-4) Alone and Combined With Docetaxel in the Treatment of Patients With Hormone Refractory Prostate Cancer (Phase 2) NCT00050596
- Monoclonal Antibody Therapy in Treating Patients With Metastatic Renal Cell Cancer (Phase 2) NCT00057889
- Monoclonal Antibody Therapy and Interleukin-2 in Treating Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT00058279
- Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer (Phase 1) NCT00060372
- Ipilimumab and Sargramostim in Treating Patients With Metastatic Prostate Cancer (Phase 1) NCT00064129
- CP-675,206 With Neoadjuvant Hormone Therapy in Patients With High Risk Prostate Cancer (Phase 1|Phase 2) NCT00075192
- Monoclonal Antibody With or Without gp100 Peptides Plus Montanide ISA-51 in Treating Patients With Stage IV Melanoma (Phase 2) NCT00077532
- Study of MDX-010 in Stage IV Breast Cancer (Phase 2) NCT00083278
- Monoclonal Antibody Therapy and Vaccine Therapy in Treating Patients With Resected Stage III or Stage IV Melanoma (Phase 2) NCT00084656
- CP-675,206 In Patients With Advanced Melanoma (Phase 2) NCT00086489
- MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma (Phase 1|Phase 2) NCT00089076
- CP-675,206 (CTLA4-Blocking Monoclonal Antibody) Combined With Dendritic Cell Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed With Surgery (Phase 1) NCT00090896
- MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma (Phase 3) NCT00094653
- MDX-010 in Treating Patients With Stage IV Pancreatic Cancer That Cannot Be Removed By Surgery (Phase 2) NCT00112580
- Vaccine and Antibody Treatment of Prostate Cancer (Phase 1) NCT00113984
- A Study of MDX-010 (BMS-734016) Administered With or Without Prophylactic Oral Budesonide (Phase 2) NCT00135408
- A Study of Anti-CTLA4 Antibody in People With Advanced Synovial Sarcoma (Phase 2) NCT00140855
- A Companion Study for Patients Enrolled in Prior/Parent Ipilimumab Studies (Phase 2) NCT00162123
- Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer (Phase 2) NCT00170157
- Study of CP-675,206 in Refractory Melanoma (Phase 2) NCT00254579
- CP-675,206 Versus Either Dacarbazine Or Temozolomide In Patients Without Prior Therapy (Phase 3) NCT00257205
- Phase II Study to Determine Predictive Markers of Response to BMS-734016 (MDX-010) (Phase 1|Phase 2) NCT00261365
- A Single Arm Study of Ipilimumab Monotherapy in Patients With Previously Treated Unresectable Stage III or IV Melanoma (Phase 2) NCT00289627
- Study of Ipilimumab (MDX-010) Monotherapy in Patients With Previously Treated Unresectable Stage III or IV Melanoma (Phase 2) NCT00289640
- Randomized Study Of CP-675,206 or Best Supportive Care Immediately After Platinum-Based Therapy For Non-Small Cell Lung Cancer (NSCLC) (Phase 2) NCT00312975
- Study of MDX-010 in Patients With Metastatic Hormone-Refractory Prostate Cancer (Phase 1|Phase 2) NCT00323882
- Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma (Phase 3) NCT00324155
- Ipilimumab With or Without Vaccine Therapy in Treating Patients With Previously Treated Stage IV Melanoma (Phase 2) NCT00357461
- Study of Neoadjuvant Ipilimumab in Patients With Urothelial Carcinoma Undergoing Surgical Resection (Phase 1) NCT00362713
- Dose-Finding Study Of CP-675,206 And SU011248 In Patients With Metastatic Renal Cell Carcinoma (Phase 1) NCT00372853
- A Rollover Study for Patients Who Received CP-675,206 in Other Protocols, to Allow the Patients Access to CP-675,206 Until This Agent Becomes Commercially Available or Development is Discontinued. (Phase 2) NCT00378482
- Study to Compare Two Formulations of CP-675,206 Monoclonal Antibody (Phase 1) NCT00431275
- Ticilimumab (CP-675,206) in Treating Patients With Stage IIIC or Stage IV Melanoma (Phase 2) NCT00471887
- Safety And Efficacy Study Of CP-675,206 In HIV-Infected Patients (Phase 2) NCT00488995
- Compassionate Use Trial for Unresectable Melanoma With Ipilimumab () NCT00495066
- Phase II Study for Previously Untreated Subjects With Non Small Cell Lung Cancer (NSCLC) or Small Cell Lung Cancer (SCLC) (Phase 2) NCT00527735
- A Phase 1 Study Testing CP-675,206 In Combination With Gemcitabine In Patients With Previously Untreated, Advanced Pancreatic Cancer (Phase 1) NCT00556023
- Treatment Use Study for Advanced Melanoma. () NCT00584493
- A Study To Assess The Safety Of Administering CP-675,206 As A One Hour Infusion In Patients With Surgically Incurable Advanced Melanoma (Phase 1) NCT00585000
- CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin’s Lymphoma, ALL & CLL (Phase 1) NCT00586391
- Evaluation of Tumor Response to Ipilimumab in the Treatment of Melanoma With Brain Metastases (Phase 2) NCT00623766
- Efficacy Study of Ipilimumab Versus Placebo to Prevent Recurrence After Complete Resection of High Risk Stage III Melanoma (Phase 3) NCT00636168
- Expression Analysis of Specific Markers in Non-small Cell Lung Cancer or Melanoma (Not Applicable) NCT00685750
- CP-675,206 in Combination With Short Term Androgen Deprivation in Patients With Stage D0 Prostate Cancer (Phase 1) NCT00702923
- Study of MDX-010 in Subjects With Unresectable Stage III or Stage IV Malignant Melanoma (Phase 1) NCT00729950
- Study of Ipilimumab and Dasatinib Combination Therapy in Patients With Chronic or Accelerated Chronic Myeloid Leukemia (Phase 1) NCT00732186
- Bevacizumab Plus Ipilimumab in Patients With Unresectable Stage III or IV Melanoma (Phase 1) NCT00790010
- Drug-Drug Interaction – 3 Arm – Carboplatin/Paclitaxel, Dacarbazine (Phase 1) NCT00796991
- Combination of Anti-CD137 & Ipilimumab in Patients With Melanoma (Phase 1) NCT00803374
- Ipilimumab +/- Vaccine Therapy in Treating Patients With Locally Advanced, Unresectable or Metastatic Pancreatic Cancer (Phase 1) NCT00836407
- Study of Immunotherapy to Treat Advanced Prostate Cancer (Phase 3) NCT00861614
- Laboratory-Treated T Cells and Ipilimumab in Treating Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT00871481
- Study of CP-675,206 in Bacillus Calmette-Guerin (BCG)-Resistant Bladder Cancer (Phase 1) NCT00880854
- Comparison of Ipilimumab Manufactured by 2 Different Processes in Participants With Advanced Melanoma (Phase 1) NCT00920907
- Long-term Data Collection for Subjects in MDX-010 Studies () NCT00928031
- Immunogenicity and Biomarker Analysis of Neoadjuvant Ipilimumab for Melanoma (Early Phase 1) NCT00972933
- Anti-CTLA-4 Human Monoclonal Antibody CP-675,206 in Patients With Advanced Hepatocellular Carcinoma (Phase 2) NCT01008358
- Dose-escalation Study of Combination BMS-936558 (MDX-1106) and Ipilimumab in Subjects With Unresectable Stage III or Stage IV Malignant Melanoma (Phase 1) NCT01024231
- Study of AntiCTLA4 in Patients With Unresectable or Metastatic Uveal Melanoma (Phase 2) NCT01034787
- Phase 3 Study of Immunotherapy to Treat Advanced Prostate Cancer (Phase 3) NCT01057810
- Tremelimumab and CP-870,893 in Patients With Metastatic Melanoma (Phase 1) NCT01103635
- Ipilimumab + Temozolomide in Metastatic Melanoma (Phase 2) NCT01119508
- Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery (Phase 2) NCT01134614
- Japanese Study of Ipilimumab Administered in Combination With Paclitaxel/Carboplatin in Patients With Nonsmall-cell Lung Cancer (Phase 1) NCT01165216
- Vaccine Combining Multiple Class I Peptides and Montanide ISA 51VG With Escalating Doses of Anti-PD-1 Antibody Nivolumab or Ipilimumab With Nivolumab For Patients With Resected Stages IIIC/ IV Melanoma (Phase 1) NCT01176474
- Neoadjuvant Ipilimumab in Prostate Cancer (Phase 2) NCT01194271
- Ipilimumab in Patients With Advanced Melanoma and Spontaneous Preexisting Immune Response to NY-ESO-1 (Phase 2) NCT01216696
- Safety and Efficacy Study of BMS-908662 in Combination With Ipilimumab in Subjects With Advanced Melanoma (Phase 1) NCT01245556
- Pilot Study of Cetuximab and the Hedgehog Inhibitor IPI-926 in Recurrent Head and Neck Cancer (Phase 1) NCT01255800
- Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery (Phase 3) NCT01274338
- Phase 3 Trial in Squamous Non Small Cell Lung Cancer Subjects Comparing Ipilimumab Versus Placebo in Addition to Paclitaxel and Carboplatin (Phase 3) NCT01285609
- Study of Pembrolizumab (MK-3475) in Participants With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, or Non-small Cell Lung Carcinoma (P07990/MK-3475-001/KEYNOTE-001) (Phase 1) NCT01295827
- Autologous TriMix-DC Therapeutic Vaccine in Combination With Ipilimumab in Patients With Previously Treated Unresectable Stage III or IV Melanoma (Phase 2) NCT01302496
- Addition of Ipilimumab (MDX-010) To Isolated Limb Infusion (ILI) With Standard Melphalan and Dactinomycin In The Treatment of Advanced Unresectable Melanoma of The Extremity (Phase 2) NCT01323517
- The Addition of Ipilimumab to Carboplatin and Etoposide Chemotherapy for Extensive Stage Small Cell Lung Cancer (Phase 2) NCT01331525
- Safety Study of Radiation and CP-675,206 Infusion for Breast Cancer Patients (Phase 1) NCT01334099
- THE IPI – Trial in Advanced Melanoma: Melanoma Patients With Advanced Disease (Phase 2) NCT01355120
- Granulocyte Macrophage-Colony Stimulating Factor and Ipilimumab as Therapy in Melanoma (Phase 2) NCT01363206
- Ipilimumab + Androgen Depravation Therapy in Prostate Cancer (Phase 2) NCT01377389
- Ph I Ipilimumab Vemurafenib Combo in Patients With v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) (Phase 1) NCT01400451
- IPI Biochemotherapy for Chemonaive Patients With Metastatic Melanoma (Phase 1) NCT01409174
- IPI-Biotherapy for Patients Previously Treated With Cytotoxic Drugs With Metastatic Melanoma (Phase 1|Phase 2) NCT01409187
- Phase I Study of Ipilimumab (Anti-CTLA-4) in Children and Adolescents With Treatment-Resistant Cancer (Phase 1) NCT01445379
- Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy (Phase 2) NCT01449279
- Trial in Extensive-Disease Small Cell Lung Cancer (ED-SCLC) Subjects Comparing Ipilimumab Plus Etoposide and Platinum Therapy to Etoposide and Platinum Therapy Alone (Phase 3) NCT01450761
- Study of Nivolumab (BMS-936558) in Combination With Gemcitabine/Cisplatin, Pemetrexed/Cisplatin, Carboplatin/Paclitaxel, Bevacizumab Maintenance, Erlotinib, Ipilimumab or as Monotherapy in Subjects With Stage IIIB/IV Non-small Cell Lung Cancer (NSCLC) (CheckMate 012) (Phase 1) NCT01454102
- Safety and Efficacy Trial of Ipilimumab Versus Pemetrexed in Non-Squamous Non-Small Cell Lung Cancer (Phase 2) NCT01471197
- Nivolumab (BMS-936558; MDX-1106) in Combination With Sunitinib, Pazopanib, or Ipilimumab in Subjects With Metastatic Renal Cell Carcinoma (RCC) (CheckMate 016) (Phase 1) NCT01472081
- Ipilimumab and Gemcitabine Hydrochloride in Treating Patients With Stage III-IV or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery (Phase 1) NCT01473940
- A Phase II Study to Evaluate Safety and Efficacy of Combined Treatment With Ipilimumab and Intratumoral Interleukin-2 (Phase 2) NCT01480323
- Safety Study of IL-21/Ipilimumab Combination in the Treatment of Melanoma (Phase 1) NCT01489059
- Tissue and Blood Biomarkers From Patients With Stage III or Stage IV Melanoma Treated With Ipilimumab With or Without Sargramostim () NCT01489423
- Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma (Phase 2) NCT01495988
- Yervoy With Sylatron Unresectable Stage 3 or 4 Melanoma (Phase 1) NCT01496807
- RADVAX邃「: A STRATIFIED PHASE I/II DOSE ESCALATION TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOLLOWED BY IPILIMUMAB IN METASTATIC MELANOMA (Phase 1|Phase 2) NCT01497808
- Ipilimumab in Combination With Androgen Suppression Therapy in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer (Phase 2) NCT01498978
- Pre-Operative, Single-Dose Ipilimumab and/or Cryoablation in Early Stage/Resectable Breast Cancer (Phase 1) NCT01502592
- Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant Prostate Cancer (Phase 1) NCT01510288
- A Multi-National, Prospective, Observational Study in Patients With Unresectable or Metastatic Melanoma () NCT01511913
- Phase 3 Trial in Subjects With Metastatic Melanoma Comparing 3 mg/kg Ipilimumab Versus 10 mg/kg Ipilimumab (Phase 3) NCT01515189
- First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma (Phase 2) NCT01524991
- Ipilimumab and GMCSF Immunotherapy for Prostate Cancer (Phase 2) NCT01530984
- Study of Radiotherapy Administered in Combination With Ipilimumab in Patients With Unresectable Stage III or Stage IV Advanced Malignant Melanoma (Phase 1) NCT01557114
- Concurrent Ipilimumab and Stereotactic Ablative Radiation Therapy (SART) for Oligometastatic But Unresectable Melanoma (Phase 2) NCT01565837
- Nivolumab and Ipilimumab in Treating Patients With Metastatic Uveal Melanoma (Phase 2) NCT01585194
- An Efficacy Study in Gastric and Gastroesophageal Junction Cancer Comparing Ipilimumab Versus Standard of Care Immediately Following First Line Chemotherapy (Phase 2) NCT01585987
- Doxycycline, Temozolomide and Ipilimumab in Melanoma (Phase 1|Phase 2) NCT01590082
- An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma (Phase 1|Phase 2) NCT01592370
- A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (Phase 1|Phase 2) NCT01604889
- Neoadjuvant Combination Therapy With Ipilimumab and HighDose IFN-ホア2b for Melanoma (Phase 1) NCT01608594
- Phase II Study of Ipilimumab Monotherapy in Recurrent Platinum-sensitive Ovarian Cancer (Phase 2) NCT01611558
- PH 1 Biomarker Study of Nivolumab and Ipilimumab and Nivolumab in Combination With Ipilimumab in Advanced Melanoma (Phase 1) NCT01621490
- Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic (Phase 1) NCT01643278
- A Combination of Ipilimumab and Fotemustine for Treat Unresectable Locally Advanced or Metastatic Melanoma (Phase 2) NCT01654692
- An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer (Phase 1|Phase 2) NCT01658878
- A Study of Intratumoral Injection of Interleukin-2 and Ipilimumab in Patients With Unresectable Stages III-IV Melanoma (Phase 1) NCT01672450
- Phase II Safety Study of Vemurafenib Followed by Ipilimumab in Subjects With V600 BRAF Mutated Advanced Melanoma (Phase 2) NCT01673854
- Ipilimumab With Carboplatin and Paclitaxel in Patients With Unresectable Stage III and Stage IV Melanoma (Phase 2) NCT01676649
- Phase 2 Study of Ipilimumab Plus Dacarbazine in Japanese Patients With Advanced Melanoma (Phase 2) NCT01681212
- Combining Ipilimumab With Abiraterone Acetate Plus Prednisone in Chemotherapy and Immunotherapy-naテッve Patients With Progressive Metastatic Castration-resistant Prostate Cancer (Phase 1|Phase 2) NCT01688492
- Study of the Combination of Anti-OX40 and Ipilimumab in Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT01689870
- Phase II Randomized Trial of Ipilimumab Versus Ipilimumab and Radiotherapy in Metastatic Melanoma (Phase 2) NCT01689974
- Ipilimumab in Treating Patients With Metastatic or Recurrent Human Papilloma Virus-Related Cervical Cancer (Phase 2) NCT01693783
- Phase 2 Study of Ipilimumab in Children and Adolescents (12 to < 18 Years) With Previously Treated or Untreated, Unresectable Stage III or Stage lV Malignant Melanoma (Phase 2) NCT01696045
- Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts (Not Applicable) NCT01701674
- Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma (Phase 1) NCT01703507
- Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery (Phase 2) NCT01708941
- Study to Compare the Effect of Ipilimumab Retreatment With That of Chemotherapy in Advanced Melanoma (Phase 2) NCT01709162
- Chemoradiation Therapy and Ipilimumab in Treating Patients With Stages IB2-IIB or IIIB-IVA Cervical Cancer (Phase 1) NCT01711515
- A Study of an Anti-KIR Antibody Lirilumab in Combination With an Anti-PD1 Antibody Nivolumab and Nivolumab Plus an Anti-CTLA-4 Ipilimumab Antibody in Patients With Advanced Solid Tumors (Phase 1|Phase 2) NCT01714739
- Study of Ipilimumab in the Immune System (Not Applicable) NCT01715077
- Ipilimumab and Rituximab in Treating Patients With Relapsed or Refractory B-cell Lymphoma (Phase 1) NCT01729806
- Radioembolization and Ipilimumab in Treating Patients With Uveal Melanoma With Liver Metastases (Early Phase 1) NCT01730157
- Ipilimumab and Imatinib Mesylate in Advanced Cancer (Phase 1) NCT01738139
- Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma (Phase 1|Phase 2) NCT01740297
- CTLA-4 Blockade and Low Dose Cyclophosphamide in Patients With Advanced Malignant Melanoma (Phase 2) NCT01740401
- Biochemotherapy and Bevacizumab Followed by Consolidation Therapy With Ipilimumab for Metastatic Melanoma (Phase 1|Phase 2) NCT01743157
- Safety Study of BMS-986015 (Anti-KIR) in Combination With Ipilimumab in Subjects With Selected Advanced Tumor (Phase 1) NCT01750580
- Ipilimumab and Lenalidomide in Advanced Cancer (Phase 1) NCT01750983
- Ipilimumab in Treating Patients With Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia (Phase 1) NCT01757639
- Clinical Evaluation of the Underlying Mechanisms of Targeted Therapy Related Toxicities () NCT01758575
- Study of Dabrafenib +/- Trametinib in Combination With Ipilimumab for V600E/K Mutation Positive Metastatic or Unresectable Melanoma (Phase 1) NCT01767454
- Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer (Phase 1|Phase 2) NCT01769222
- Study of Nivolumab Given Sequentially With Ipilimumab in Subjects With Advanced or Metastatic Melanoma (CheckMate 064) (Phase 2) NCT01783938
- Aldesleukin Imaging in Viewing Tumor Growth in Patients With Stage IV Melanoma Receiving Ipilimumab or Pembrolizumab Therapy (Early Phase 1) NCT01789827
- Sipuleucel-T With Immediate vs. Delayed Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade for Prostate Cancer (Phase 2) NCT01804465
- NY-ESO-1 Vaccine in Combination With Ipilimumab in Patients With Unresectable or Metastatic Melanoma (Phase 1) NCT01810016
- Evaluation of Circulating T Cells and Tumor Infiltrating Lymphocytes (TILs) During / After Pre-Surgery Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) (Phase 2) NCT01820754
- Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant (Phase 1) NCT01822509
- Phase II Study of Abraxane Plus Ipilimumab in Patients With Metastatic Melanoma (Phase 2) NCT01827111
- Sipuleucel-T and Ipilimumab for Advanced Prostate Cancer (Phase 1) NCT01832870
- Phase I Study of Intralesional Bacillus Calmette-Guerin (BCG) Followed by Ipilimumab in Advanced Metastatic Melanoma (Phase 1) NCT01838200
- Pilot Study Evaluating the Efficacy and Safety of Metformin in Melanoma (Phase 2) NCT01840007
- Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011) (Phase 1) NCT01840579
- Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067) (Phase 3) NCT01844505
- HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma (Phase 4) NCT01856023
- Study to Evaluate the Safety and Efficacy of Two Different Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Participants With Advanced Melanoma (MK-3475-006/KEYNOTE-006) (Phase 3) NCT01866319
- A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab With Allogenic GM-CSF Transfected Pancreatic Tumor Vaccine in the Treatment of Metastatic Pancreatic Cancer (Phase 2) NCT01896869
- Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma (Phase 1|Phase 2) NCT01896999
- Study of the Drug Ipilimumab for Metastatic Merkel Cell Carcinoma (Phase 2) NCT01913691
- Lenalidomide and Ipilimumab After Stem Cell Transplant in Treating Patients With Hematologic or Lymphoid Malignancies (Phase 2) NCT01919619
- Study of Nivolumab (BMS-936558) Plus Ipilimumab Compared With Ipilimumab Alone in the Treatment of Previously Untreated, Unresectable, or Metastatic Melanoma (Phase 2) NCT01927419
- A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors (Phase 1|Phase 2) NCT01928394
- Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer (Phase 1) NCT01935921
- Ipilimumab With or Without Dabrafenib, Trametinib, and/or Nivolumab in Treating Patients With Melanoma That Is Metastatic or Cannot Be Removed by Surgery (Phase 1) NCT01940809
- SRS (Stereotactic Radiosurgery) Plus Ipilimumab (Phase 1) NCT01950195
- Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery (Phase 2) NCT01950390
- Phase II Trial of Stereotactic Body Radiotherapy Followed by Ipilimumab in Treating Patients With Stage IV Melanoma (Phase 2) NCT01970527
- Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumor Lysate or Homogenate Combined With Immunomodulating Radiotherapy and/or Preleukapheresis IFN-alfa in Patients With Metastatic Melanoma: a Randomized “Proof-of-principle” Phase II Study (Phase 2) NCT01973322
- MSB0010445 and Stereotactic Body Radiation Therapy in Advanced Melanoma (Phase 2) NCT01973608
- A Two-arm, Single Center Phase 1b Trial of Bavituximab Plus Ipilimumab in Advanced Melanoma Patients (Phase 1) NCT01984255
- LTX-315 in Patients With Transdermally Accessible Tumours as Monotherapy or Combination With Ipilimumab or Pembrolizumab (Phase 1) NCT01986426
- Clinical Evaluation of Yervoy in Combination With Adoptive T Cell Transfer for Metastatic Melanoma Patients (Phase 2) NCT01988077
- Phase 2 Study of Ipilimumab in Japanese Advanced Melanoma Patients (Phase 2) NCT01990859
- A Pilot Study of Ipilumimab and Radiation in Poor Prognosis Melanoma (Phase 1) NCT01996202
- Combination Checkpoint Inhibitor Plus Erlotinib or Crizotinib for EGFR or ALK Mutated Stage IV Non-small Cell Lung Cancer (Phase 1) NCT01998126
- Ipilimumab Administered to Stage IIIC Stage IV Melanoma After Reg. T Cell Depletion With Denileukin Diftitox (Phase 2) NCT02009384
- A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients (Phase 1|Phase 2) NCT02009397
- A Study of the Effectiveness and Safety of Nivolumab Compared to Bevacizumab and of Nivolumab With or Without Ipilimumab in Glioblastoma Patients (Phase 3) NCT02017717
- Combining Ipilimumab, Degarelix, and Radical Prostatectomy in Men With Newly Diagnosed Metastatic Castration Sensitive Prostate Cancer or Ipilimumab and Degarelix in Men With Biochemically Recurrent Castration Sensitive Prostate Cancer After Radical Prostatectomy (Phase 2) NCT02020070
- Cellular Adoptive Immunotherapy Using Autologous CD8+ Antigen-Specific T Cells and Anti-CTLA4 (Phase 2) NCT02027935
- Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma (Phase 1) NCT02032810
- A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Non-small Cell Lung Cancer (MK-3475-021/KEYNOTE-021) (Phase 1|Phase 2) NCT02039674
- Small Cell Lung Carcinoma Trial With Nivolumab and IpiliMUmab in LImited Disease (Phase 2) NCT02046733
- Ipilimumab 12-month Intensive Pharmacovigilance Protocol () NCT02050594
- Immunotherapy Study for Patients With Stage IV Melanoma (Phase 2) NCT02054520
- An Investigational Immuno-therapy Study of Nivolumab, and Nivolumab in Combination With Other Anti-cancer Drugs, in Colon Cancer That Has Come Back or Has Spread (Phase 2) NCT02060188
- A National Phase IV Study With Ipilimumab for Patients With Advanced Malignant Melanoma. (Phase 4) NCT02068196
- Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies (Phase 1) NCT02070406
- Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT02073123
- Vaccination With Peptides in Combination With Either Ipilimumab or Vemurafenib for the Treatment of Unresectable Stage III or IV Malignant Melanoma (Phase 1) NCT02077114
- Program for Pembrolizumab (MK-3475) in Participants With Metastatic Melanoma Who Have Failed Standard of Care Therapy Including Ipilimumab (MK-3475-030) () NCT02083484
- Safety and Tolerability of Pembrolizumab (MK-3475) + Pegylated Interferon Alfa-2b and Pembrolizumab+ Ipilimumab in Participants With Advanced Melanoma or Renal Cell Carcinoma (MK-3475-029/KEYNOTE-29) (Phase 1|Phase 2) NCT02089685
- Trial of Ipilimumab After Isolated Limb Perfusion, in Patients With Metastases Melanoma (Phase 2) NCT02094391
- Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery (Phase 2) NCT02097732
- Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma (Phase 2) NCT02107755
- T-Cell Responses to Neoantigens Post Treatment With Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer (Early Phase 1) NCT02113657
- GEM STUDY: Radiation And Yervoy in Patients With Melanoma and Brain Metastases (Phase 2) NCT02115139
- Trial of Neoadjuvant Ipilimumab Followed by Melphalan Via Isolated Limb Infusion for Patients With Unresectable In-transit Extremity Melanoma (Phase 1) NCT02115243
- Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma (Phase 1) NCT02117362
- Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer (Phase 2|Phase 3) NCT02154490
- Nab-Paclitaxel and Bevacizumab or Ipilimumab as First-Line Therapy in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery (Phase 2) NCT02158520
- A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors (Phase 1) NCT02174172
- Expanded Access Program With Nivolumab in Combination With Ipilimumab in Patients With Tumors Unable to be Removed by Surgery or Metastatic Melanoma () NCT02186249
- Adjuvant Therapy of Completely Resected Merkel Cell Carcinoma With Immune Checkpoint Blocking Antibodies vs Observation (Phase 2) NCT02196961
- Ipilimumab and Dabrafenib in the 1st Line Tx of Unresectable Stage III/IV Melanoma (Phase 1) NCT02200562
- High-Dose Aldesleukin and Ipilimumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed By Surgery (Phase 2) NCT02203604
- Adoptive Therapy Using Antigen-Specific CD4 T-Cells (Phase 1) NCT02210104
- Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery (Early Phase 1) NCT02210117
- Study of Combined Ionizing Radiation and Ipilimumab in Metastatic Non-small Cell Lung Cancer (NSCLC) (Phase 2) NCT02221739
- YERVOYツョ Risk Minimization Tool Effectiveness Evaluation Survey () NCT02224768
- Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma (Phase 3) NCT02224781
- Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214) (Phase 3) NCT02231749
- Ipilimumab and Stereotactic Body Radiation Therapy (SBRT) in Advanced Solid Tumors (Phase 1|Phase 2) NCT02239900
- A Phase I/II Study of Intratumoral Injection of SD-101 (Phase 1|Phase 2) NCT02254772
- RTA 408 Capsules in Patients With Melanoma – REVEAL (Phase 1|Phase 2) NCT02259231
- Neoadjuvant Nivolumab, or Nivolumab in Combination With Ipilimumab, in Resectable NSCLC (Phase 2) NCT02259621
- A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma (Phase 2) NCT02272855
- Safety of UV1 Vaccination in Combination With Ipilimumab in Patients With Unresectable or Metastatic Malignant Melanoma (Phase 1|Phase 2) NCT02275416
- Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanoma (Phase 3) NCT02278887
- Phase 3 Trial in Squamous Non Small Cell Lung Cancer Subjects Comparing Ipilimumab Plus Paclitaxel and Carboplatin Versus Placebo Plus Paclitaxel and Carboplatin (Phase 3) NCT02279732
- Safety and Efficacy Study of Ipilimumab 3 mg/kg Versus Ipilimumab 10 mg/kg in Subjects With Metastatic Castration Resistant Prostate Cancer Who Are Chemotherapy Naive (Phase 2) NCT02279862
- Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas (Phase 1|Phase 2) NCT02304458
- Neoadjuvant Pembrolizumab for Unresectable Stage III and Unresectable Stage IV Melanoma (Phase 2) NCT02306850
- Intratumoral CAVATAK (CVA21) and Ipilimumab in Patients With Advanced Melanoma (VLA-013 MITCI) (Phase 1) NCT02307149
- Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma (Phase 1) NCT02311920
- Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer (Phase 2) NCT02314169
- An Investigational Immuno-therapy Study to Evaluate Safety and Effectiveness in Patients With Melanoma That Has Spread to the Brain, Treated With Nivolumab in Combination With Ipilimumab, Followed by Nivolumab by Itself (Phase 2) NCT02320058
- Nivolumab and Ipilimumab With or Without Sargramostim in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery (Phase 2|Phase 3) NCT02339571
- Evaluate the Mediators of Sensitivity and Resistance to Nivolumab Plus Ipilimumab in Patients With Advanced NSCLCs (Phase 2) NCT02350764
- Anti窶娠D 1 Brain Collaboration for Patients With Melanoma Brain Metastases (Phase 2) NCT02374242
- Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer (Phase 1) NCT02381314
- A Phase I/II Trial to Evaluate a Peptide Vaccine Plus Ipilimumab in Patients With Melanoma (Phase 1|Phase 2) NCT02385669
- Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma (CheckMate 238) (Phase 3) NCT02388906
- Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia (Phase 2) NCT02397720
- Ipilimumab 60-month Pharmacovigilance Protocol for Advanced Melanoma Patients Who Are Hepatitis B and/or Hepatitis C Virus Positive in Taiwan () NCT02402699
- Ipilimumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma (Phase 2) NCT02403778
- Trial of SBRT With Concurrent Ipilimumab in Metastatic Melanoma (Phase 1) NCT02406183
- Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery (Phase 1) NCT02408861
- A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma (Phase 1|Phase 2) NCT02413827
- Phase I Clinical Trial of Cryoimmunotherapy Against Prostate Cancer (Phase 1) NCT02423928
- Nivolumab Alone or in Combination With Ipilimumab in Treating Patients With Advanced Uterine Leiomyosarcoma (Phase 2) NCT02428192
- Study to Identify the Optimal Adjuvant Combination Scheme of Ipilimumab and Nivolumab in Melanoma Patients (Phase 1) NCT02437279
- Investigation of Circulating Tumor Cells From Cancer Patients Undergoing Radiation Therapy () NCT02449837
- Pilot Study to Evaluate the Effects of a Vaccine (HSPPC-96) Combined With Ipilimumab in Patients With Advanced Melanoma (Phase 1|Phase 2) NCT02452281
- Buparlisib in Melanoma Patients Suffering From Brain Metastases (BUMPER) (Phase 2) NCT02452294
- Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer (Phase 1) NCT02453620
- A Study of Fotemustine(FTM) Vs FTM and Ipilimumab (IPI) or IPI and Nivolumab in Melanoma Brain Metastasis (Phase 3) NCT02460068
- A Study of BBI608 Administered in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Cancers (Phase 1|Phase 2) NCT02467361
- Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer (Phase 1) NCT02475213
- An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC) (Phase 3) NCT02477826
- An Investigational Immuno-therapy Study to Investigate the Safety and Effectiveness of Nivolumab, and Nivolumab Combination Therapy in Virus-associated Tumors (Phase 1|Phase 2) NCT02488759
- PAN-EU Utilization, Effectiveness and Safety of Ipilimumab Administered in EAP Patients With Advanced Melanoma () NCT02492815
- Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors (Phase 1) NCT02496208
- Nivolumab With or Without Ipilimumab in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer (Phase 2) NCT02498600
- Cytokine-induced Killer Study for Patients With Stage II Melanoma (Phase 2) NCT02498756
- Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery (Phase 2) NCT02500797
- Neoadjuvant PROSTVAC-VF With or Without Ipilimumab for Prostate Cancer (Phase 2) NCT02506114
- High-Dose Recombinant Interferon Alfa-2B, Ipilimumab, or Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery (Phase 3) NCT02506153
- A Phase 1 Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Ipilimumab in Chinese Subjects With Select Advanced Solid Tumors (Phase 1) NCT02516527
- Nivolumab With or Without Ipilimumab or Relatlimab Before Surgery in Treating Patients With Stage IIIB-IV Melanoma That Can Be Removed by Surgery (Phase 2) NCT02519322
- Immunotherapy With Nivolumab or Nivolumab Plus Ipilimumab vs. Double Placebo for Stage IV Melanoma w. NED (Phase 2) NCT02523313
- Nivolumab and Ipilimumab With 5-azacitidine in Patients With Myelodysplastic Syndromes (MDS) (Phase 2) NCT02530463
- MEDI4736 and Tremelimumab in Treating Patients With Metastatic HER2 Negative Breast Cancer (Phase 2) NCT02536794
- An Investigational Immuno-therapy Study of Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based Chemotherapy (Phase 3) NCT02538666
- A Comparative Study in Chinese Subjects With Chemotherapy Naテッve Stage IV Melanoma Receiving Ipilimumab (3 mg/kg) vs. Dacarbazine (Phase 3) NCT02545075
- Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab (CA209-260) (Phase 2) NCT02553642
- Multi-Centre, Retrospective, Open Label Study, to Validate ML-PrediCare by Patients With Melanoma Under 1st and 2nd Lines of Immunotherapy () NCT02581228
- Nivolumab Combined With Ipilimumab Followed by Nivolumab Monotherapy as First-Line Treatment for Patients With Advanced Melanoma (Phase 3) NCT02599402
- Identification of Predictive Parameters for Colitis in Melanoma Patients Treated With Immunotherapy. () NCT02600143
- Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7 (Phase 2) NCT02601014
- A Study Investigating SGI-110 in Combination With Ipilimumab in Unresectable or Metastatic Melanoma Patients (Phase 1) NCT02608437
- Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases (Phase 2) NCT02621515
- Tremelimumab With or Without Cryoablation in Treating Patients With Metastatic Kidney Cancer (Not Applicable) NCT02626130
- Trial of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated Metastatic Uveal Melanoma (Phase 2) NCT02626962
- Sequential Combo Immuno and Target Therapy (SECOMBIT) Study (Phase 2) NCT02631447
- A Study to Assess the Safety and Efficacy of Intratumoral IMO-2125 in Combination With Ipilimumab or Pembrolizumab in Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT02644967
- An Open-Label Phase II Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma (Phase 2) NCT02648997
- BrUOG 324: Adjuvant Nivolumab and Low Dose Ipilimumab for Stage III and Resected Stage IV Melanoma: A Phase II Brown University Oncology Research Group Trial (Phase 2) NCT02656706
- An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread (Phase 1|Phase 2) NCT02658890
- Nivolumab in Combination With Ipilimumab (Part 1); Nivolumab Plus Ipilimumab in Combination With Chemotherapy (Part 2) as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (Phase 2) NCT02659059
- A Pilot Study to Evaluate the Safety and Efficacy of Combination Checkpoint Blockade Plus External Beam Radiotherapy in Subjects With Stage IV Melanoma (Phase 1) NCT02659540
- Ipilimumab Combined With a Stereotactic Radiosurgery in Melanoma Patients With Brain Metastases (Phase 2) NCT02662725
- Ipilimumab (Immunotherapy) and MGN1703 (TLR Agonist) in Patients With Advanced Solid Malignancies (Phase 1) NCT02668770
- Safety and Efficacy of MIW815 (ADU-S100) +/- Ipilimumab in Patients With Advanced/Metastatic Solid Tumors or Lymphomas (Phase 1) NCT02675439
- Check Point Inhibition After Autologous Stem Cell Transplantation in Patients at High Risk of Post Transplant Recurrence (Phase 1|Phase 2) NCT02681302
- TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (Phase 2) NCT02693535
- Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer (Phase 1|Phase 2) NCT02696993
- RATIO: Rational Approach To Immuno-Oncology (Not Applicable) NCT02700971
- Tremelimumab and Durvalumab With or Without Radiation Therapy in Patients With Relapsed Small Cell Lung Cancer (Phase 2) NCT02701400
- Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer (Phase 2) NCT02703623
- A Study of Two Different Dose Combinations of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated, Unresectable or Metastatic Melanoma (Phase 3) NCT02714218
- Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients (Phase 2) NCT02716272
- Yervoyツョ Postmarketing Surveillance for Patients in Japan With Unresectable, Malignant Melanoma () NCT02717364
- Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma (Phase 1) NCT02723006
- Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy (Phase 2) NCT02731729
- Neoadjuvant Combination Biotherapy With Ipilimumab and Nivolumab or Nivolumab Alone (Phase 1|Phase 2) NCT02736123
- An Investigational Immuno-therapy Study of Experimental Medication BMS-986178 by Itself or in Combination With Nivolumab and/or Ipilimumab in Patients With Solid Cancers That Are Advanced or Have Spread (Phase 1|Phase 2) NCT02737475
- Study of Autoimmune Disease Complications Following Ipilimumab Treatment Among Melanoma Patients With Underlying Autoimmune Diseases () NCT02739386
- Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (Phase 3) NCT02741570
- Pembrolizumab and Ipilimumab After Prior Immunotherapy for Melanoma (Phase 2) NCT02743819
- An Investigational Immuno-therapy Study to Test Combination Treatments in Patients With Advanced Non-Small Cell Lung Cancer (Phase 2) NCT02750514
- Tremelimumab and Durvalumab in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery (Phase 1) NCT02754856
- Ipilimumab-induced Lung Toxicity: Observational Study () NCT02755233
- An Investigational Study of Infliximab With Prednisone or Methylprednisolone Versus Prednisone Combination Treatment in Immune Related or Severe Diarrhea in Patients Treated With Yervoy and/or Opdivo (Phase 2) NCT02763761
- Study in Patients With Unresectable And Metastatic Melanoma: The Optimize Study () NCT02780089
- GI Complications in Cancer Immunotherapy Patients () NCT02784366
- Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers (Phase 3) NCT02785952
- Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma (Phase 2) NCT02794883
- Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery (Phase 1) NCT02812420
- Ipilimumab for Head and Neck Cancer Patients (Phase 1) NCT02812524
- Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (Phase 2) NCT02823574
- Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas (Phase 1) NCT02829931
- A Study of Pre-Operative Treatment With Cryoablation and Immune Therapy in Early Stage Breast Cancer (Not Applicable) NCT02833233
- Nivolumab and Ipilimumab in Treating Patients With Rare Tumors (Phase 2) NCT02834013
- Single Agent and Combined Inhibition After Allogeneic Stem Cell Transplant (Phase 1) NCT02846376
- Yervoy Pregnancy Surveillance Study () NCT02854488
- A Trial Evaluating the Safety & Efficacy of Intra-Tumoral Ipilimumab in Combination With Intra-venous Nivolumab in Patients With Metastatic Melanoma (Phase 1|Phase 2) NCT02857569
- A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in NSCLC Patients With EGFR Mutation Who Failed 1L or 2L EGFR TKI Therapy (Phase 3) NCT02864251
- Immune Checkpoint Inhibition in Combination With Radiation Therapy in Pancreatic Cancer or Biliary Tract Cancer Patients (Phase 2) NCT02866383
- An Investigational Immuno-therapy Study for Safety of Nivolumab in Combination With Ipilimumab to Treat Advanced Cancers (Phase 4) NCT02869789
- Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer (Phase 3) NCT02872116
- Blinatumomab and Nivolumab With or Without Ipilimumab in Treating Patients With Poor-Risk Relapsed or Refractory CD19+ Precursor B-Lymphoblastic Leukemia (Phase 1) NCT02879695
- Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery (Phase 2) NCT02880020
- Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer (Phase 2) NCT02888743
- Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia (Phase 1) NCT02890329
- Ipilimumab and Nivolumab in Treating Patients With Recurrent Stage IV HER2 Negative Inflammatory Breast Cancer (Phase 2) NCT02892734
- Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients (Phase 3) NCT02899299
- JTX-2011 Alone and in Combination With Anti-PD-1 or Anti-CTLA-4 in Subjects With Advanced and/or Refractory Solid Tumors (Phase 1|Phase 2) NCT02904226
- A Safety and Efficacy Study of Multiple Administration Regimens for Nivolumab Plus Ipilimumab in Subjects With Melanoma (Phase 3) NCT02905266
- Yttrium90, Ipilimumab, & Nivolumab for Uveal Melanoma With Liver Metastases (Phase 1|Phase 2) NCT02913417
- Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Renal Cell Carcinoma (Phase 2) NCT02917772
- Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity (Phase 2) NCT02919683
- IL2 Imaging in Metastatic Melanoma (Not Applicable) NCT02922283
- A Study of RGX-104 in Patients With Advanced Solid Malignancies and Lymphoma (Phase 1) NCT02922764
- A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers (Phase 2) NCT02923934
- A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer (Phase 2) NCT02935634
- Selective HDAC6 Inhibitor ACY-241 in Combination With Ipilimumab and Nivolumab (Phase 1) NCT02935790
- Definition of an Immune Signature Predictive of Anti-PD1 (Programmed Death-1) Antibody in the Treatment of Advanced Melanoma () NCT02938728
- Ipilimumab and Nivolumab in Leptomeningeal Metastases (Phase 2) NCT02939300
- Real-Life Efficacy and Safety of Nivolumab in Patients With Advanced/Metastatic Renal Cell Carcinoma After Prior Therapy () NCT02940639
- A Clinical Trial: Adjuvant Low-dose Ipilimumab + Nivolumab After Resection of Melanoma Macrometastases (Phase 1|Phase 2) NCT02941744
- A Study Combining NeoVax, a Personalized NeoAntigen Cancer Vaccine, With Ipilimumab to Treat High-risk Renal Cell Carcinoma (Phase 1) NCT02950766
- Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer With BRCA1 or BRCA2 Mutation (Phase 2) NCT02953457
- A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naテッve Metastatic Kidney Cancer (Phase 2) NCT02960906
- Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy (Phase 2) NCT02968303
- Study of Combination of Ipilimumab and Nivolumab in Patients With Melanoma (Phase 2) NCT02970981
- Optimal Neo-adjuvant Combination Scheme of Ipilimumab and Nivolumab (Phase 2) NCT02977052
- Immunization Strategy With Intra-tumoral Injections of Pexa-Vec With Ipilimumab in Metastatic / Advanced Solid Tumors. (Phase 1) NCT02977156
- A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab (Phase 2) NCT02978443
- A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma (Phase 2) NCT02982486
- A Study to Evaluate the Safety of Nivolumab and Ipilimumab in Subjects With Previously Untreated Advanced or Metastatic Renal Cell Cancer (Phase 4) NCT02982954
- A Dose Escalation and Cohort Expansion Study of CD122-Biased Cytokine (NKTR-214) in Combination With Anti-PD-1 Antibody (Nivolumab) or in Combination With Nivolumab and Anti-CTLA4 Antibody (Ipilimumab) in Patients With Select Advanced or Metastatic Solid Tumors (Phase 1|Phase 2) NCT02983045
- Study of Nivolumab Plus Ipilimumab, Ipilimumab or Cabazitaxel in Men With Metastatic Castration-Resistant Prostate Cancer (Phase 2) NCT02985957
- Real-Life Efficacy and Safety of Nivolumab Monotherapy or in Combination With Ipilimumab in Patients With Advanced (Unresectable or Metastatic) Melanoma and in Patients With Adjuvant Nivolumab Therapy () NCT02990611
- Atezolizumab With Stereotactic Ablative Radiotherapy in Patients With Metastatic Tumours (Phase 2) NCT02992912
- A Study to Test Combination Treatments in People With Advanced Renal Cell Carcinoma (Phase 2) NCT02996110
- A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) (Phase 3) NCT02998528
- An Exploratory Study of the Effects of Nivolumab Combined With Ipilimumab in Patients With Treatment-Naive Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) (Phase 2) NCT03001882
- ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma (Phase 1|Phase 2) NCT03003637
- Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Liver (Phase 1) NCT03005002
- Study of IMM 101 in Combination With Standard of Care in Patients With Metastatic or Unresectable Cancer (Phase 1|Phase 2) NCT03009058
- PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas (Phase 1|Phase 2) NCT03013491
- Durvalumab and Tremelimumab in Treating Participants With Recurrent or Refractory Ovarian, Primary Peritoneal, or Fallopian Tube Cancer (Phase 2) NCT03026062
- Nivolumab, Ipilimumab and COX2-inhibition in Early Stage Colon Cancer: an Unbiased Approach for Signals of Sensitivity (Phase 2) NCT03026140
- A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer (Phase 1|Phase 2) NCT03026166
- An Investigational Immuno-Therapy Safety and Efficacy Study of Multiple Administration Regimens for Nivolumab Plus Ipilimumab in Subjects With Renal Cell Carcinoma (Phase 2) NCT03029780
- Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That Is Stage IV or Stage III and Cannot Be Removed by Surgery (Phase 2) NCT03033576
- Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Patients With Untreated Inoperable or Metastatic Urothelial Cancer (Phase 3) NCT03036098
- Ipilimumab + Nivolumab w/Thoracic Radiotherapy for Extensive-Stage Small Cell Lung Cancer (Phase 1|Phase 2) NCT03043599
- A Safety Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Non-small Cell Lung Cancer (Phase 3) NCT03048136
- Ipilimumab and Nivolumab in the Treatment of Malignant Pleural Mesothelioma (Phase 2) NCT03048474
- Precise Local Injection of Anti-cancer Drugs Using Presage’s CIVO邃「 Device in Soft Tissue Sarcoma (Phase 1) NCT03056599
- Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature (Phase 2) NCT03061539
- Trial of SBRT in Combination With Nivolumab/Ipilimumab in RCC / Kidney Cancer Patients (Phase 2) NCT03065179
- An Investigational Immuno-therapy Study of Nivolumab Combined With Ipilimumab Compared to Nivolumab by Itself After Complete Surgical Removal of Stage IIIb/c/d or Stage IV Melanoma (Phase 3) NCT03068455
- Autologous CD8+ SLC45A2-Specific T Lymphocytes With Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Participants With Metastatic Uveal Melanoma (Phase 1) NCT03068624
- Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma (Phase 2) NCT03070392
- Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma (Phase 2) NCT03071406
- Randomized Phase-II Study of Nivolumab Plus Ipilimumab vs. Standard of Care in Untreated and Advanced Non-clear Cell RCC (Phase 2) NCT03075423
- BIOLUMA: Biomarkers for Nivolumab and Ipilimumab and Evaluation of the Combination in Lung Cancer (Phase 2) NCT03083691
- Study of Nivolumab Verses Nivolumab and Ipilimumab Combination in EGFR Mutant Non-small Cell Lung Cancer (Phase 2) NCT03091491
- Phase 2 Trial of Ipilimumab and Nivolumab in Nasopharyngeal Carcinoma (Phase 2) NCT03097939
- Immunotherapy Study of Evofosfamide in Combination With Ipilimumab (Phase 1) NCT03098160
- Study of Nivolumab in Combination With Gemcitabine/Cisplatin or Ipilimumab for Patients With Advanced Unresectable Biliary Tract Cancer (Phase 2) NCT03101566
- Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer (Phase 2) NCT03104439
- First-In-Human Study of Monoclonal Antibody BMS-986218 by Itself and in Combination With Nivolumab in Patients With Advanced Solid Tumors (Phase 1|Phase 2) NCT03110107
- Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell Carcinoma (Phase 2) NCT03117309
- A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy (Phase 2) NCT03122522
- Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies (Phase 1|Phase 2) NCT03126110
- SAbR Plus Ipilimumab Plus Nivolumab in Metastatic Melanoma Patients (Phase 2) NCT03126461
- An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies (Phase 2) NCT03130959
- Durvalumab and Tremelimumab Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Stage II-III Breast Cancer (Early Phase 1) NCT03132467
- SAINT:Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma (Phase 1|Phase 2) NCT03138161
- A Study Comparing the Combination of Nivolumab and Ipilimumab Versus Placebo in Participants With Localized Renal Cell Carcinoma (Phase 3) NCT03138512
- Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases () NCT03140137
- A Study of Nivolumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (Phase 3) NCT03141177
- A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin (Phase 3) NCT03143153
- Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer (Phase 1) NCT03144778
- Nivolumab and Ipilimumab in Treating Patients With Metastatic/Recurrent ACC of All Sites and Non-ACC Salivary Gland Cancer (Phase 2) NCT03146650
- Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation in Patients With Metastatic Clear-Cell RCC (ccRCC) Who Have Failed Treatment With Single-Agent Nivolumab (Phase 2) NCT03149159
- A Study of Combination With TBI-1401(HF10) and Ipilimumab in Japanese Patients With Unresectable or Metastatic Melanoma (Phase 2) NCT03153085
- Nivolumab With or Without Ipilimumab or Chemotherapy in Treating Patients With Previously Untreated Stage I-IIIA Non-small Cell Lung Cancer (Phase 2) NCT03158129
- Evaluation of Denosumab in Combination With Immune Checkpoint Inhibitors in Patients With Unresectable or Metastatic Melanoma (Phase 1|Phase 2) NCT03161756
- Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer (Early Phase 1) NCT03162731
- Cost of Adverse Events Related to How Often Follow-Up Occurs Among Patients With Cancer That Has Spread () NCT03165409
- A Real-World Study of Ipilimumab Treatment After Nivolumab Treatment in Melanoma in Japan () NCT03165422
- Radiation and Immune Checkpoints Blockade in Metastatic NSCLC (BMS # CA209-632) (Phase 1|Phase 2) NCT03168464
- Exercise as a Supportive Measure for Patients Undergoing Checkpoint-inhibitor Treatment (Phase 2) NCT03171064
- Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer (Phase 2) NCT03172624
- Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602) (Phase 2) NCT03177239
- Study of CRS-207, Nivolumab, and Ipilimumab With or Without GVAX Pancreas Vaccine (With Cy) in Patients With Pancreatic Cancer (Phase 2) NCT03190265
- Study of Nivolumab in Combination With Ipilimumab in Chinese Subjects With Previously Treated Advanced or Recurrent Solid Tumors (Phase 1|Phase 2) NCT03195478
- Stereotactic Body Radiotherapy (SBRT) Followed by Immunotherapy in Liver Cancer (Phase 1) NCT03203304
- Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study) (Phase 2) NCT03203473
- A Safety Study of Lirilumab in Combination With Nivolumab or in Combination With Nivolumab and Ipilimumab in Advanced and/or Metastatic Solid Tumors (Phase 1) NCT03203876
- Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer (Phase 2) NCT03204812
- A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC (Phase 3) NCT03215706
- Nivolumab and Ipilimumab in Classical Kaposi Sarcoma (CKS) (Phase 2) NCT03219671
- Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Transitional Cell Carcinoma (Phase 2) NCT03219775
- Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma (Phase 2) NCT03220009
- Nivolumab With or Without Ipilimumab in Treating Patients With Resectable Liver Cancer (Phase 2) NCT03222076
- Concurrent or Sequential Immunotherapy and Radiation Therapy in Patients With Metastatic Lung Cancer (Phase 1) NCT03223155
- Nivolumab +/- Ipilimumab Immunomonitoring in Metastatic Melanoma (Not Applicable) NCT03225365
- Safety and Pharmacokinetics of REGN2810 (Anti-PD-1) in Japanese Patients With Advanced Malignancies (Phase 1) NCT03233139
- Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma (Phase 1) NCT03233152
- Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib (Phase 2) NCT03235245
- A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies (Phase 1|Phase 2) NCT03241173
- Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma (Phase 2) NCT03241186
- Nivolumab Plus Ipilimumab in Thyroid Cancer (Phase 2) NCT03246958
- A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors (Phase 1|Phase 2) NCT03251924
- Nivolumab in Combination With Chemotherapy, or Nivolumab in Combination With Ipilimumab, in Advanced EGFR-Mutant or ALK-Rearranged NSCLC (Phase 2) NCT03256136
- Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer. (Phase 2) NCT03262779
- Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation (Phase 1|Phase 2) NCT03271047
- Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma (Phase 2) NCT03274258
- Study of Lenalidomide/Dexamethasone With Nivolumab and Ipilimumab in Patients With Newly Diagnosed Multiple Myeloma (Phase 1) NCT03283046
- Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC) (Phase 2) NCT03285321
- TIL Therapy in Combination With Checkpoint Inhibitors for Metastatic Ovarian Cancer (Phase 1|Phase 2) NCT03287674
- TNF-Inhibitor as Immune Checkpoint Inhibitor for Advanced MELanoma (Phase 1) NCT03293784
- Adoptive Cell Therapy Across Cancer Diagnoses (Phase 1|Phase 2) NCT03296137
- Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma (Phase 1|Phase 2) NCT03297463
- Nivolumab in Combination With Ipilimumab in Patients With Metastatic Renal Cell Carcinoma (Phase 2) NCT03297593
- Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (Phase 2) NCT03297606
- Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-small Cell Lung Cancer (MK-3475-598/KEYNOTE-598) (Phase 3) NCT03302234
- Nivolumab/Ipilimumab-Primed Immunotransplant for DLBCL (Phase 1|Phase 2) NCT03305445
- Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery (Phase 2) NCT03307616
- Expanded Access for Pembrolizumab (MK-3475) () NCT03311542
- Uptake and Biodistribution of 89Zirconium-labeled Ipilimumab in Ipilimumab Treated Patients With Metastatic Melanoma (Phase 2) NCT03313323
- Study of Adverse Renal Effects of Immune Checkpoints Inhibitors () NCT03316417
- Glembatumumab Vedotin, Nivolumab, and Ipilimumab in Treating Patients With Advanced Metastatic Solid Tumors That Cannot Be Removed by Surgery (Phase 1|Phase 2) NCT03326258
- Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors (Phase 2) NCT03333616
- An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment (Phase 1) NCT03335540
- Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) (Phase 2) NCT03340129
- Combination of Nivolumab and Ipilimumab in Breast, Ovarian and Gastric Cancer Patients (Phase 2) NCT03342417
- A Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies (ECHO-208) (Phase 1|Phase 2) NCT03347123
- TNF in Melanoma Patients Treated With Immunotherapy (Not Applicable) NCT03348891
- Interest of iRECIST Evaluation for DCR for Evaluation of Patients With Deficient MMR and /or MSI Metastatic Colorectal Cancer Treated With Nivolumab and Ipilimumab (Phase 2) NCT03350126
- Randomized Phase III Study Testing Nivolumab and Ipilimumab Versus a Carboplatin Based Doublet in First Line Treatment of PS 2 or Elderly Patients With Advanced Non-small Cell Lung Cancer (Phase 3) NCT03351361
- ANRS CO24 OncoVIHAC (Onco VIH Anti Checkpoint) () NCT03354936
- Induction of Immune-mediated aBscOpal Effect thrOugh STEreotactic Radiation Therapy in Metastatic Melanoma Patients Treated by PD-1 + CTLA-4 Inhibitors (BOOSTER MELANOMA) (Phase 1|Phase 2) NCT03354962
- BrUOG 354 Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas (Phase 2) NCT03355976
- Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma (Phase 2) NCT03367715
- An Investigational Immunotherapy Study of BMS-986249 Alone and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread (Phase 1|Phase 2) NCT03369223
- VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer (Phase 1) NCT03373188
- Durvalumab and Tremelimumab in Treating Patients With Recurrent Stage IV Lung Cancer (Phase 2) NCT03373760
- Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung Cancer (Phase 1|Phase 2) NCT03377023
- An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Patients With Previously Treated Cancer of the Colon or Rectum That Has Spread (Phase 1|Phase 2) NCT03377361
- Evaluation of Reporting of Immune Checkpoint Inhibitor Associated Cardio-vascular Adverse Reactions () NCT03387540
- Neo-Adjuvant Bladder Urothelial Carcinoma COmbination-immunotherapy (Phase 1) NCT03387761
- Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers (Phase 1) NCT03388632
- Phase III Trial of (LCT) After Nivolumab and Ipilimumab (Phase 3) NCT03391869
- Prostaglandin Inhibition and Immune Checkpoint Blockade in Melanoma (Phase 2) NCT03396952
- Niraparib + Ipilimumab or Nivolumab in Progression Free Pancreatic Adenocarcinoma After Platinum-Based Chemotherapy (Phase 1|Phase 2) NCT03404960
- Immunotherapy in Head and Neck Squamous Cell Carcinoma : Phase 2 Trial Evaluating the Efficacy and the Toxicity of Nivolumab Alone, and of the Combination Nivolumab and Ipilimumab (Phase 2) NCT03406247
- Combination Immunotherapy-Ipilimumab-Nivolumab-Dendritic Cell p53 Vac – Patients With Small Cell Lung Cancer (SCLC) (Phase 2) NCT03406715
- A Dose-Escalation Study of MDX-010 Administered Monthly as Immunotherapy in Subjects Infected With Human Immunodeficiency Virus (HIV) (Phase 1) NCT03407105
- CAVATAKツョ and Ipilimumab in Uveal Melanoma Metastatic to the Liver (VLA-024 CLEVER) (Phase 1) NCT03408587
- Biomarkers of Immune-Related Toxicity () NCT03409016
- Phase IIb Study Evaluating Immunogenic Chemotherapy Combined With Ipilimumab and Nivolumab in Breast Cancer (Phase 2) NCT03409198
- Combinations of Cemiplimab (Anti-PD-1 Antibody) and Platinum-based Doublet Chemotherapy in Patients With Lung Cancer (Phase 3) NCT03409614
- Ipilimumab or FOLFOX in Combination With Nivolumab and Trastuzumab in HER2 Positive EsophagoGastric Adenocarcinoma (Phase 2) NCT03409848
- A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer (Phase 2) NCT03416244
- Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors (Phase 2) NCT03420521
- Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma (Phase 1) NCT03422094
- A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer (Phase 1) NCT03425292
- Biomarkers of Response to Ipilimumab and Nivolumab in First-line NSCLC (Phase 2) NCT03425331
- Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma (Phase 1) NCT03425461
- A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer (Phase 2) NCT03430063
- Trial of Combination TTF(Optune), Nivolumab Plus/Minus Ipilimumab for Bevacizumab-naテッve, Recurrent Glioblastoma (Phase 2) NCT03430791
- Combination of Chemoradiation With Immunotherapy in Inoperable ナ都ophageal Cancer (Phase 2) NCT03437200
- Survival Study for Participants Treated With Ipilimumab-Nivolumab Combination Therapy () NCT03438279
- PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC (Phase 2) NCT03442569
- Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence (Phase 2) NCT03443856
- An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination With Nivolumab and Ipilimumab in Participants With Solid Cancers That Have Spread or Cannot be Removed (Phase 1) NCT03444753
- A Study of IMO-2125 in Combination With Ipilimumab Versus Ipilimumab Alone in Subjects With Anti-PD-1 Refractory Melanoma (ILLUMINATE-301) (Phase 3) NCT03445533
- Study of First-line Treatment Patterns and Clinical Outcomes in Patients With Advanced Melanoma in the United Kingdom () NCT03448497
- Long Term Quality of Life in Melanoma Patients in Netherlands () NCT03450876
- Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers (Phase 1) NCT03452332
- Investigation of the Timely-coordinated Therapy of Patients With Metastatic Cancer by Radiotherapy Together With Immune Checkpoint Inhibition () NCT03453892
- Improved Therapy Response Assessment in Metastatic Brain Tumors () NCT03458455
- An Investigational Study of Immunotherapy Combinations in Participants With Solid Cancers That Are Advanced or Have Spread (Phase 1|Phase 2) NCT03459222
- An Expanded Access Program of Ipilimumab for Patients With Glioblastomas and Gliomas () NCT03460782
- Nivolumab Ipilimumab in Patients With hyperMutated Cancers Detected in Blood (NIMBLe) (Phase 2) NCT03461952
- Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma (Early Phase 1) NCT03463408
- Nivolumab, Cabozantinib S-Malate, and Ipilimumab in Treating Patients With Recurrent Stage IV Non-small Cell Lung Cancer (Phase 2) NCT03468985
- Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancEr (Phase 3) NCT03469960
- Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver (Phase 2) NCT03472586
- Stereotactic Body Radiation Therapy With REGN2810 and/or Ipilimumab Before Surgery in Treating Participants With Progressive Advanced or Oligometastatic Prostate Cancer (Phase 1) NCT03477864
- Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction () NCT03492242
- Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade (Phase 1) NCT03493932
- Combined Immunotherapy and Radiosurgery for Metastatic Colorectal Cancer (Phase 1) NCT03507699
- Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis (Phase 1) NCT03508570
- Phase I Multicenter Trial Combining Nivolumab, Ipilimumab and Hypo-fractionated Radiotherapy for Pretreated Advanced Stage Non-small Cell Lung Cancer Patients (Phase 1) NCT03509584
- Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC) (Phase 2) NCT03510871
- REGN2810 (Anti-PD-1 Antibody), Platinum-based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in Patients With Lung Cancer (Phase 3) NCT03515629
- A Study to Test the Safety of Immunotherapy With Nivolumab Alone or With Ipilimumab Before Surgery for Bladder Cancer Patients Who Are Not Suitable for Chemotherapy (Phase 2) NCT03520491
- Nivolumab Alone or Plus Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma (Phase 2) NCT03521830
- Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (Phase 1|Phase 2) NCT03522584
- ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors (Phase 1|Phase 2) NCT03525795
- A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytes (Early Phase 1) NCT03526185
- Anti-CTLA-4 Antibody Followed by Anti-PD-1 Antibody in Recurrent or Metastatic NSCLC (Phase 1) NCT03527251
- Study of Adjuvant Ipilimumab and Nivolumab in Subjects With High-risk Ocular Melanoma (Phase 2) NCT03528408
- Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer (Phase 1) NCT03532217
- UV1 Vaccine With Pembrolizumab for Patients With Unresectable or Metastatic Melanoma (Phase 1) NCT03538314
- Peri-Operative Ipilimumab+Nivolumab and Cryoablation Versus Standard Care in Women With Triple-negative Breast Cancer (Phase 2) NCT03546686
- Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Phase 2) NCT03548428
- Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell Carcinoma (Phase 2) NCT03552380
- Melanoma Metastasized to the Brain and Steroids (Phase 2) NCT03563729
- A Phase 1b Study of the Selective HDAC Inhibitor Mocetinostat in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma (Phase 1) NCT03565406
- Immunotherapy in Patients With Metastatic Cancers and CDK12 Mutations (Phase 2) NCT03570619
- Phase II Clinical Trial of NIVO-IPI-TAXANE in Untreated Metastatic NSCLC (Phase 2) NCT03573947
- A Phase I/II Study of Nivolumab, Ipilimumab and Plinabulin in Patients With Recurrent Small Cell Lung Cancer (Phase 1|Phase 2) NCT03575793
- Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer (Phase 1|Phase 2) NCT03581487
- Nivolumab +/- Ipilimumab in Patients With Advanced, Refractory Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Tumors (NECs) (Phase 2) NCT03591731
- A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma (Phase 1) NCT03597282
- PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma (Phase 2) NCT03598816
- Nivolumab and Ipilimumab After Donor Stem Cell Transplant in Treating Patients With High Risk Refractory or Relapsed Acute Myeloid Leukemia or Myelodysplastic Syndrome (Phase 1) NCT03600155
- Radiation Therapy and Durvalumab With or Without Tremelimumab in Treating Participants With Unresectable, Locally Advanced, or Metastatic Bladder Cancer (Phase 2) NCT03601455
- Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma (Phase 1|Phase 2) NCT03604978
- Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery (Phase 2|Phase 3) NCT03604991
- Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner (Phase 1|Phase 2) NCT03618134
- CMP-001 in Combo With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease (Phase 2) NCT03618641
- A Randomized Phase II Study on the Optimization of Immunotherapy in Squamous Carcinoma of the Head and Neck (Phase 2) NCT03620123
- Evaluation of Sphingolipids as Predictive Biomarkers of Immune Checkpoint Inhibitor Response in Melanoma Patients (Not Applicable) NCT03627026
- CTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and Tremelimumab (Phase 2) NCT03638141
- A Study of a Personalized Neoantigen Cancer Vaccine (Phase 1|Phase 2) NCT03639714
- Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma (Phase 2) NCT03646617
- Modified FOLFOX Plus/Minus Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Gastric Cancer (Phase 2) NCT03647969
- Nivolumab, Ipilimumab, and Bicalutamide in Human Epidermal Growth Factor (HER) 2 Negative Breast Cancer Patients (Phase 2) NCT03650894
- Treatment With Nivolumab and Ipilimumab or Nivolumab Alone According to the Percentage of Tumoral CD8 Cells in Advanced Metastatic Cancer (Phase 2) NCT03651271
- Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable Non-Small Cell Lung Cancer (NSCLC) (Phase 1|Phase 2) NCT03663166
- A Study to Observe the Onset of Immune-related Adverse Reactions in Patients With Non-surgical or Renal Cell Carcinoma (RCC) That Has Spread () NCT03663946
- A Study of Nivolumab Combined With Ipilimumab and Nivolumab Alone in Patients With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H) (Phase 2) NCT03668119
- A Pilot Study of Combination Immunotherapy With Ipilimumab and Nivolumab in Patients With Recurrent Extensive Stage Small Cell Lung Cancer (SCLC) Who Have Previously Received Platinum-based Chemotherapy (Phase 2) NCT03670056
- Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma (Phase 1|Phase 2) NCT03682276
- VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer (Phase 1) NCT03690986
- INTERVAL: Ipilimumab and Nivolumab Combination Therapy: A Study of a Supervised or Semi-Supervised Exercise InteRVention or Usual Care With Functional Capacity and Quality of Life Evaluations in Subjects With Advanced or Metastatic RenAL Cell Carcinoma (Not Applicable) NCT03692338
- A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors (Phase 2) NCT03693014
- Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors (Phase 2) NCT03693846
- A Data Collection Study for Patients With Adenocarcinoma Treated With the MyVaccx Immunotherapy Regimen. () NCT03695835
- Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy (Phase 3) NCT03700905
- Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma (Phase 1) NCT03707457
- Intratumoral Injection of Autologous CD1c (BDCA-1)+ myDC, Avelumab, and Ipilimumab Plus Systemic Nivolumab (Phase 1) NCT03707808
- A Study of IMM-101 in Combination With Checkpoint Inhibitor Therapy in Advanced Melanoma (Phase 2) NCT03711188
- Rituximab and Hyaluronidase Human in Patients With Advanced Melanoma Undergoing Nivolumab and Ipilimumab Therapy (Phase 2) NCT03719131
- Nivolumab Plus Relatlimab or Ipilimumab in Metastatic Melanoma Stratified by MHC-II Expression (Phase 2) NCT03724968
- RACIN in Patients With Advanced TIL-negative Solid Tumors (Phase 1) NCT03728179
- Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma (Phase 2) NCT03728465
- A Comparison of Nivolumab-based Treatments in a Real-world PD-L1 Positive Metastatic Melanoma Population in the US () NCT03732560
- Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers (Phase 1|Phase 2) NCT03749460
- Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome (Phase 2) NCT03767439
- VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma (Phase 1) NCT03769155
- Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer (Phase 1|Phase 2) NCT03776487
- Nivolumab, Ipilimumab and OTSGC-A24 Therapeutic Peptide Vaccine in Gastric Cancer – a Combination Immunotherapy Phase Ib Study. (Phase 1) NCT03784040
- NIMBUS: Nivolumab Plus Ipilimumab in Metastatic Hypermutated HER2-negative Breast Cancer (Phase 2) NCT03789110
- Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study (Phase 3) NCT03793166
- Nivolumab and Radiation Therapy or Ipilimumab as Adjuvant Therapy in Treating Patients With Merkel Cell Cancer (Phase 1) NCT03798639
- Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma (Phase 2) NCT03799445
- CAcTUS – Circulating Tumour DNA Guided Switch (Phase 2) NCT03808441
- Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers (Phase 1) NCT03816332
- Anetumab Ravtansine With Nivolumab, Ipilimumab and Gemcitabine Hydrochloride in Treating Patients With Mesothelin Positive Advanced Pancreatic Cancer (Phase 1) NCT03816358
- Evaluate the Clinical Benefit of a Post-operative Treatment Associating Radiotherapy + Nivolumab + Ipilimumab Versus Radiotherapy + Capecitabine for Triple Negative Breast Cancer Patients With Residual Disease (Phase 2) NCT03818685
- An Open-label, Randomized, Parallel, Non Comparative, Phase II Trial of Nivolumab Plus Ipilimumab Versus Platinum-based Chemotherapy Plus Nivolumab in Chemonaive Metastatic or Recurrent Squamous-Cell Lung Cancer (SqLC) (Phase 2) NCT03823625
- CBM588, Nivolumab, and Ipilimumab in Treating Patients With Stage IV or Advanced Kidney Cancer (Phase 1) NCT03829111
- NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Microsatellite Stable, MGMT Silenced Metastatic Colorectal Cancer (Phase 2) NCT03832621
- A Study of Mitomycin-c/ Capecitabine ChemoRadiotherapy Combined With Nivolumab Monotherapy or Ipilumimab and Nivolumab, as Bladder Sparing Curative Treatment for Muscle Invasive Bladder Cancer: the CRIMI Study (Phase 1|Phase 2) NCT03844256
- Radiation and Combination Immunotherapy for Melanoma (Phase 2) NCT03850691
- Study of Tilsotolimod in Combination With Nivolumab and Ipilimumab for the Treatment of Solid Tumors (ILLUMINATE-206) (Phase 2) NCT03865082
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors (Phase 2) NCT03866382
- Autoantibodies in Treatment With Immune Checkpoint Inhibitors (AUTENTIC) () NCT03868046
- An Immunotherapy Study of Nivolumab Plus Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer (Phase 3) NCT03873402
- Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain (Phase 2) NCT03873818
- A Personalized Medicine Study for Patients With Advanced Cancer of the Breast, Prostate, Pancreas or Those With Refractory Acute Myelogenous Leukemia (Phase 1) NCT03878524
- A Trial of Immunotherapy Strategies in Metastatic Hormone-sensitive Prostate Cancer (Phase 2|Phase 3) NCT03879122
- Optune Device – TT Field Plus Nivolumab and Ipilimumab for Melanoma With Brain Metastasis (Phase 2) NCT03903640
- A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT (Phase 1) NCT03912064
- Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer (Phase 2) NCT03914300
- Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma (Phase 1|Phase 2) NCT03918252
- Study of Immunotherapy Plus ADI-PEG 20 for the Treatment of Advanced Uveal Melanoma (Phase 1) NCT03922880
- Neoantigen Vaccine Plus Locally Administered Ipilimumab and Systemic Nivolumab in Advanced Melanoma (Phase 1) NCT03929029
- Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (Phase 3) NCT03937219
- Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors (Phase 2) NCT03945773
- Cryotherapy With in Situ Immunotherapy in Melanoma Metastasis (Phase 1|Phase 2) NCT03949153
- A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens (Phase 1|Phase 2) NCT03953235
- An Investigational Immunotherapy Study of BMS-986301 Alone or in Combination With Nivolumab, and Ipilimumab in Participants With Advanced Solid Cancers (Phase 1) NCT03956680
- IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma (Phase 1|Phase 2) NCT03958383
- Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma (Phase 2) NCT03959293
- Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial (Phase 3) NCT03977571
- A Study to Assess Safety and Efficacy of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-PD-1 Treatment (Phase 1) NCT03978611
- Study of Intratumoral Ipilimumab and TLR4 Agonist GLA-SE in Combination With Systemic Nivolumab and Chemotherapy (Phase 1) NCT03982121
- Vopratelimab and a CTLA-4 Inhibitor in PD-1/PD-L1 Inhibitor Experienced Subjects With NSCLC or Urothelial Cancer (Phase 2) NCT03989362
- PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors (Phase 2) NCT03993379
- A Phase II Study of the Interleukin-6 Receptor Inhibitor Tocilizumab in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma (Phase 2) NCT03999749
- IL13Ralpha2-Targeted Chimeric Antigen Receptor (CAR) T Cells With or Without Nivolumab and Ipilimumab in Treating Patients With Recurrent or Refractory Glioblastoma (Phase 1) NCT04003649
- Peri-operative Association of Immunotherapy (Pre-operative Association of Nivolumab and Ipilimumab, Post-operative Nivolumab Alone) in Localized Microsatellite Instability (MSI) and/or Deficient Mismatch Repair (dMMR) Oeso-gastric Adenocarcinoma (Phase 2) NCT04006262
- A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanoma (Phase 2) NCT04007588
- A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator’s Choice Chemotherapy for the Treatment of Patients With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (Phase 3) NCT04008030
- Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer (Phase 1) NCT04013542
- Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab (Phase 2) NCT04013854
- BMS-986156, Ipilimumab, and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver Cancers (Phase 1|Phase 2) NCT04021043
- Safety and Efficacy of Sonocloud Device Combined With Nivolumab in Brain Metastases From Patients With Melanoma (Phase 1|Phase 2) NCT04021420
- A Study of Nivolumab and Ipilimumab in Untreated Patients With Stage 3 NSCLC That is Unable or Not Planned to be Removed by Surgery (Phase 3) NCT04026412
- ImmunoPET With an Anti-CD8 Imaging Agent (Phase 1|Phase 2) NCT04029181
- Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer (Phase 2) NCT04034927
- A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma (Phase 3) NCT04039607
- Nivolumab and Ipilimumab in People With Aggressive Pituitary Tumors (Phase 2) NCT04042753
- Nivolumab and Ipilimumab in Combination With Immunogenic Chemotherapy for Patients With Advanced NSCLC (Phase 1|Phase 2) NCT04043195
- A Prospective Observational Study of Renal Cell Cancer Patients Treated With Nivolumab Plus Ipilimumab in the Real World Setting in Japan () NCT04043975
- CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI) (Phase 1|Phase 2) NCT04060407
- Perioperative Chemotherapy vs Immunotherapy vs. Chemo-immunotherapy in Patients With Advanced GC and AEG (Phase 2) NCT04062656
- Study of ARRY-614 Plus Either Nivolumab or Ipilimumab (Phase 1|Phase 2) NCT04074967
- Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors (Phase 2) NCT04079712
- Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer (Phase 2) NCT04080804
- A Study of Combination Nivolumab and Ipilimumab Retreatment in Patients With Advanced Renal Cell Carcinoma (Phase 2) NCT04088500
- SBRT With Combination Ipilimumab/Nivolumab for Metastatic Kidney Cancer (Phase 2) NCT04090710
- A Phase 2 Trial for Men With Metastatic Prostatic Adenocarcinoma (Phase 2) NCT04090775
- Nivolumab/Ipilimumab Plus Cabozantinib in Patients With Unresectable Advanced Melanoma (Phase 2) NCT04091750
- Polarized Dendritic Cell (aDC1) Vaccine, Interferon Alpha-2, Rintalolimid, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma (Phase 2) NCT04093323
- Microbiome Immunotherapy Toxicity and Response Evaluation () NCT04107168
- Phase IB/II Study of Nivolumab in Combination w Radium-223 in Men w Metastatic Castration Resistant Prostate Cancer (Phase 1|Phase 2) NCT04109729
- Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected MMR-p Colorectal and Pancreatic Cancer (Phase 1) NCT04117087
- Ipilimumab +Nivolumab + Cryotherapy in Metastatic or Locally Advanced Soft Tissue Sarcoma (Phase 2) NCT04118166
- Neoadjuvant Chemoradiotherapy With Sequential Ipilimumab and Nivolumab in Rectal Cancer (Phase 2) NCT04124601
- Nivolumab/Ipilimumab in Second Line CUP-syndrome (Phase 2) NCT04131621
- A Study of Multiple Immune and Disease Treatment Combinations in Participants With ER+HER2-Breast Cancer That Has Spread (Phase 1) NCT04132817
- Multicenter Phase 1b Trial Testing the Neoadjuvant Combination of Domatinostat, Nivolumab and Ipilimumab in IFN-gamma Signature-low and IFN-gamma Signature-high RECIST 1.1-measurable Stage III Cutaneous or Unknown Primary Melanoma (Phase 1|Phase 2) NCT04133948
- Nivolumab and Ipilimumab in T1aN0M0 Renal Cell Carcinoma Patients Ineligible for Surgical Treatment. (Phase 2) NCT04134182
- BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics () NCT04136470
- PhIb Study Evaluating Safety and Efficacy of Combination Osimertinib and Ipilimumab in Patients w EGFR Mutated NSCLC (Phase 1) NCT04141644
- A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) for People With Recurrent Glioblastoma With Elevated Mutational Burden (Phase 2) NCT04145115
- AImmune – Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient’s Response to Immunotherapies. () NCT04145232
- Breathomics as Predictive Biomarker for Checkpoint Inhibitor Response () NCT04146064
- CaboCHECK – Cabozantinib in Adult Patients With Advanced Renal Cell Carcinoma Following Prior Systemic Check Point Inhibition Therapy: a Retrospective, Non-interventional Study () NCT04147143
がん免疫療法 免疫チェックポイント阻害薬(ICI) Ipilimumabの効果 ~抗CTLA-4抗体~
2018年に本庶佑博士とともにノーベル医学生理学賞を受賞したジェームス・アリソン博士が、最初の臨床試験のことを語るインタビュー動画。
2015 Lasker DeBakey Clinical Medical Research Award 2015/09/07 Albert and Mary Lasker Foundation
Talks@12: Immunotherapy: An Answer to Cancer? 2017/11/07 Harvard Medical School
抗CTLA-4抗体(免疫チェックポイント阻害薬)の最初の臨床試験で効果があった患者さんのストーリー
Sharon Belvinさんのストーリー
上の動画でも登場したSharon Belvinさんのストーリー。
She’s the Answer to Cancer…and So Are You 2016/05/06 Cancer Research Institute
- Milestones in Medicine: How Immunotherapy Began in Cancer Care A look back at how immunotherapy began in oncology. (ARLENE WEINTRAUB SEPTEMBER 25, 2019 curetoday.com) Sharon Belvin was 23 and running out of options to treat her stage 4 melanoma in 2005 when her oncologist at Memorial Sloan Kettering Cancer Center in New York City offered to enter her in a clinical trial of a drug designed to empower her immune system to fight the cancer. By that point, she had progressed after several rounds of chemotherapy, plus radiosurgery to remove tumors that had spread to her brain. The drug blocked CTLA-4, a protein “checkpoint” that prevents the immune system from recognizing and attacking cancer. After just four treatments, 60% of Belvin’s tumors were gone. Within months, they had all disappeared, and she has been cancer-free ever since. In 2011, that drug, Yervoy (ipilimumab), became the first checkpoint inhibitor to be approved by the Food and Drug Administration (FDA).
- For this Nobel winner, fighting cancer began with his family (Oct 1, 2018 6:25 PM EST PBS) アリソン博士が2018年ノーベル医学生理学賞を受賞した直後のPBS NEWSのインタビュー動画(7:26)トランスクリプト付き
- Melanoma survivor’s unlikely recovery leads to lifestyle changes (Oct 1, 2017 sungazette.com) The treatment involved 90-minute infusions and injections in Belvin’s leg. … But the radiologist had never seen anything like it. He had to verify he’d grabbed the right labs. My tumors had shrunk by 60 percent in that first round.
- A Scientist’s Dream Fulfilled: Harnessing The Immune System To Fight Cancer (June 9, 2016 3:41 PM ET Heard on All Things Considered NPR) Sharon Belvin’s nightmare with cancer began in 2004, when she was just 22.
- Six Miracle Cancer Survivors (Robert Langreth Mar 2, 2009, 04:50pm forbes.com) An experimental drug helped Sharon Belvin, who was diagnosed with melanoma in her lung when she was 22 and spent two years in standard treatment. The drug is called ipilimumab, and it aims to trigger the immune system against cancer. Within four months, her lung tumors started to shrivel. By late 2006, they were gone. Today Belvin, now 27, is off all treatment.
Tom Telfordさんのストーリー
- How the Promise of Immunotherapy Is Transforming Oncology (Tom Telfordさんのストーリー WSJ ) He had surgery at Memorial Sloan Kettering Cancer Center, followed by months of chemotherapy. But the disease spread to his liver and kidneys. The diagnosis: Stage 4 melanoma, a skin cancer typically fatal within a year. “Death is not an option,” he told his doctor. Nine years later, against all odds, Mr. Telford is still alive. What saved him was an experimental immunotherapy drug—a medication that unleashes the body’s own immune system to attack cancer.
ipilimumabをFDAが承認
On 25 March, the FDA cleared ipilimumab, produced by Bristol-Myers Squibb, based in New York, to treat advanced melanoma, a particularly lethal form of skin cancer. Although the drug typically lengthens a patient’s life by only 4 months or so, in clinical trials a fraction of patients lived much longer.
Although ipilimumab can add years of life, only 20–30% of patients show any benefit at all (F. S. Hodi et al. N. Engl. J. Med. 363, 711–723; 2010).
(引用元:Melanoma drug wins US approval. Nature volume 471, page 561 (2011) 28 March 2011)
臨床試験
- MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma (Phase 3)(NCT00094653) Study Type : Interventional (Clinical Trial) Actual Enrollment : 1783 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Multicenter Study Comparing MDX-010 Monotherapy, MDX-010 in Combination With a Melanoma Peptide Vaccine, and Melanoma Vaccine Monotherapy in HLA-A2*0201-Positive Patients With Previously Treated Unresectable Stage III or IV Melanoma Study Start Date : September 2004 Actual Primary Completion Date : August 2009 Actual Study Completion Date : October 2009
- IPILIMUMABの臨床試験(NIH ClinicalTrials.govデータベースの検索結果)
臨床試験の結果を報告した論文
- The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: patient cases. Cancer Immun. 2008; 8: 1. Published online 2008 Jan 17. PMCID: PMC2935787 Results from preclinical and early clinical trials support currents phase II/III testing of ipilimumab as first- and second-line therapy for metastatic melanoma.
- CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood. 2009 Feb 12;113(7):1581-8. doi: 10.1182/blood-2008-07-168468. Epub 2008 Oct 30. Twenty-nine patients with malignancies that were recurrent or progressive after allo-HCT, received ipilimumab as a single infusion at dose cohorts between 0.1 and 3.0 mg/kg. … Three patients with lymphoid malignancy developed objective disease responses following ipilimumab: complete remission (CR) in 2 patients with Hodgkin disease and partial remission (PR) in a patient with refractory mantle cell lymphoma. At the 3.0 mg/kg dose, active serum concentrations of ipilimumab were maintained for more than 30 days after a single infusion. Ipilimumab, as administered in this clinical trial, does not induce or exacerbate clinical GVHD, but may cause organ-specific IAE and regression of malignancy.
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma. August 19, 2010 N Engl J Med 2010; 363:711-723 DOI: 10.1056/NEJMoa1003466 METHODS A total of 676 HLA-A*0201–positive patients with unresectable stage III or IV melanoma, whose disease had progressed while they were receiving therapy for metastatic disease, were randomly assigned, in a 3:1:1 ratio, to receive ipilimumab plus gp100 (403 patients), ipilimumab alone (137), or gp100 alone (136). RESULTS The median overall survival was 10.0 months among patients receiving ipilimumab plus gp100, as compared with 6.4 months among patients receiving gp100 alone (hazard ratio for death, 0.68; P<0.001). CONCLUSIONS Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
- A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma. Investigational New Drugs June 2011, Volume 29, Issue 3, pp 489–498 (Free abstract)
- Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma. J Clin Oncol. 2015 Jun 10;33(17):1889-94. doi: 10.1200/JCO.2014.56.2736. Epub 2015 Feb 9.
- Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. October 5, 2017 N Engl J Med 2017; 377:1345-1356 DOI: 10.1056/NEJMoa1709684 2つのICIを併用した効果をみたもの
抗CTLA-4抗体の効果を調べた初期の論文
- Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996 Mar 22;271(5256):1734-6. (PDF) We reasoned that CTLA-4 blockade would remove inhibitory signals in the costimulatory pathway, resulting in enhanced rejection of the tumor cells. We injected groups of BALB/c mice …
脳震盪とは concussion / a mild traumatic brain injury (mTBI)
脳震盪とは
“Concussion Management” by Michael O’Brien for OPENPediatrics 2018/08/10 OPENPediatrics
- スポーツ脳震盪 (MSDメルクマニュアルプロフェッショナル版)
Concussions: Heading for Change – an NET Sports Feature 2014/11/12 NETNebraska
スポーツ脳震盪のアセスメント
SCAT5 – Sport Concussion Assessment Toolの実際。
SCAT5 – Sport Concussion Assessment Tool 2018/07/18 Aspetar
ディープウェブとダークウェブ
通常のインターネットブラウザでアクセスしているのは、インターネット全体のほんの氷山の一角なのだそうです。水面下にある部分はディープウェブと言われます。ディープウェブの一部に、ダークウェブがあります。
Why You Should Never Visit The Dark Web 2019/01/31 The Infographics Show
マクロライド系抗生物質の作用機序
マクロライド系抗生物質の作用機序
Macrolides: Mechanisms of Action and Resistance 2011/03/30 Mechanisms in Medicine
エクソソームの検出、定量キットの使い方の実際【動画による説明】
How to use ExoTEST Kit (kit for exosome capture and quantification) 2015/07/25 HansaBioMed Life Sciences Ltd
シェーグレン症候群 (Sjögren症候群)とは
シェーグレン症候群とは
シェーグレン症候群は1933年にスウェーデンの眼科医ヘンリック・シェーグレンの発表した論文にちなんでその名前がつけられた疾患です。日本では1977年の厚生労働省研究班の研究によって医師の間に広く認識されるようになりました。 本疾患は主として中年女性に好発する涙腺と唾液腺を標的とする臓器特異的自己免疫疾患ですが、全身性の臓器病変を伴う全身性の自己免疫疾患でもあります。シェーグレン症候群は膠原病(関節リウマチ、全身性エリテマトーデス、強皮症、皮膚筋炎、混合性結合組織病) に合併する二次性シェーグレン症候群と、これらの合併のない原発性シェーグレン症候群に分類されます。(指定難病53 難病情報センター)
シェーグレン症候群の症状
一部の患者では、口または眼の乾燥だけがみられます。… 多数の臓器が侵される場合もあります。シェーグレン症候群では、鼻、咽頭、消化管、喉頭、気管、気管支、外陰部、腟の表面を覆っている粘膜が乾燥することがあります。(MSDマニュアル家庭版)
- シェーグレン症候群 (SS)(MSDマニュアル プロフェッショナル版)
Sjögren’s syndrome 2014/02/25 Dr. Andras Fazakas
シェーグレン症候群の病態・診断・治療、診療ガイドライン
- シェーグレン症候群診療ガイドライン2017年版(130ページPDF) 厚生労働科学研究費補助金 難治性疾患等政策研究事業 自己免疫疾患に関する調査研究班
- シェーグレン症候群:病態・診断・治療 (第 114 回日本内科学会講演会 超世代の内科学―GeneralityとSpecialtyの先へ― 本講演は,平成29年4月16日(日)東京都・東京国際フォーラムにて行われた.)
- 成人のシェーグレン症候群の特徴と治療(総 説 臨床リウマチ,29: 219~227,2017)
シェーグレン症候群の診断基準
シェーグレン症候群(SjS)改訂診断基準(厚生労働省研究班、1999 年)
1.生検病理組織検査で次のいずれかの陽性所見を認めること
A)口唇腺組織でリンパ球浸潤が 1/4m ㎡当たり 1focus 以上
B)涙腺組織でリンパ球浸潤が 1/4m ㎡当たり 1focus 以上
2.口腔検査で次のいずれかの陽性所見を認めること
A)唾液腺造影で stage I(直径 1mm 以下の小点状陰影)以上の異常所見
B)唾液分泌量低下(ガムテスト 10 分間で 10mL 以下,またはサクソンテスト 2 分間 2g 以下)があり、かつ唾液腺シンチグラフィーにて機能低下の所見
3.眼科検査で次のいずれかの陽性所見を認めること
A)Schirmer 試験で 5mm/5min 以下で、かつローズベンガルテスト(van Bijsterveld スコア)で陽性
B)Schirmer 試験で 5mm/5min 以下で、かつ蛍光色素(フルオレセイン)試験で陽性
4.血清検査で次のいずれかの陽性所見を認めること
A)抗 SS-A 抗体陽性
B)抗 SS-B 抗体陽性診断 以上1、2、3、4のいずれか2項目が陽性であればシェーグレン症候群と診断する。(転載元)
抗SS-A抗体と抗SS-B抗体
これらの自己抗体の名前の由来に関しては、下のレビューでわかりやすく解説されています。
Anti-Ro/SSA and anti-La/SSB antibodies were originally described in 1961 as two precipitating antibodies reacting with antigens contained in extracts from salivary and lacrimal glands of patients with SS, termed SjD, and SjT, respectively [9]. SjD antigen was reported to be insensitive to trypsin or heat, while SjT antigen could be destroyed by the same treatment. In 1969, Clark et al. described the presence of antibodies in the sera of patients with SLE that reacted with ribonucleoprotein (RNP) antigens present in extracts of rabbit and human spleen [10]. The authors named the antibody “anti-Ro antibody” after the original patient in whom the antibodies were identified. The same group also found antibodies to another soluble cytoplasmic RNA protein antigen, “La” [11]. At about the same time, Alspaugh and Tan noted the existence of autoantibodies in the sera of many SS patients, which react with antigens termed “SSA” and “SSB,” [12]. SSB antigen was described also as “Ha”, an antigen targeted by sera from patients with SLE and SS [13]. Later, Ro and La were demonstrated to be antigenically identical to SSA and SSB [14]. (Clinical and Developmental Immunology Volume 2012, Article ID 606195, 12 pages http://dx.doi.org/10.1155/2012/606195 Review Article Clinical and Pathological Roles of Ro/SSA Autoantibody System Ryusuke Yoshimi, Atsuhisa Ueda, Keiko Ozato, and Yoshiaki Ishigatsubo 著作権:CC BY 3.0)
抗SS-A/Ro抗体と抗SS-B/La抗体は共に非ヒストン核蛋白抗体のひとつであり,シェーグレン症候群と密接に関連している。しかし,抗SS-A抗体は多くの膠原病で陽性を示す。(抗SS-A/Ro抗体 SRL総合案内)
異常値を示す主な疾患・状態・異常高値:シェーグレン症候群の50~70% 全身性エリテマトーデス(SLE)の40~60% 重複症候群の40~60% 強皮症の10~30% 多発性筋炎/皮膚筋炎の10~20% 関節リウマチの20~30%(抗SS-A/Ro抗体 FALCO臨床検査案内サイト)
抗SS-A抗体はシェーグレン症候群の70~90%と最も高頻度に検出されますが、疾患特異性は高くなく、全身性エリテマトーデス(SLE)や強皮症、混合性結合組織病(MCTD)、関節リウマチなど他の膠原病でも広く陽性となります。RNAと蛋白の複合体に対する自己抗体で、対応抗原は細胞質に多く存在するため抗核抗体陰性でも抗SS-A抗体が検出されることがあります。 一方、抗SS-B抗体はシェーグレン症候群の30~40%に検出され、特異性が高く、抗SS-B抗体陽性の場合、抗SS-A抗体も同時に陽性となります。RNAポリメラーゼIIIの転写産物と複合体を形成する蛋白に対する自己抗体で、対応抗原は核内に存在するため抗核抗体ではSpeckled型陽性を示します。(CRC)
- 抗 SS-A 抗体陽性女性の妊娠に関する診療の手引き (2013 年 3 月 平成 22 年度~平成 24 年度 厚生労働科学研究費補助金 成育疾患克服等次世代育成基盤研究事業)抗 SS-A 抗体は全身性エリテマトーデス(SLE)やシェーグレン症候群(SS)で高率に認められる自己抗体であるが、無症候性の女性が保有している場合もある。抗 SS-A 抗体陽性女性から出生する児における NLE の発症率は約 10%、そのうち CHBは約1%(すなわち、全国での年間発症数は約100 例)と推定されている[2]。
- シェーグレン症候群患者が妊娠する場合に注意することはありますでしょうか?(FAQ 指定難病53 難病情報センター) 抗SS-A抗体という抗体をお持ちですと、新生児に房室ブロックという不整脈が出ることがまれにあります。また、新生児ループスといって、生まれた赤ちゃんにお母さんの自己抗体が移行し、真っ赤になって(赤ちゃんはもともと赤いから赤ちゃんなのですがさらに真っ赤に)生まれる事がまれにあります。
- Franceschini F, Cavazzana. Anti-Ro/SSA and La/SSB antibodies. Autoimmunity. 2005 Feb;38(1):55-63. (PubMed) The Ro/La system is considered as an heterogeneous antigenic complex, constituted by three different proteins (52 kDa Ro, 60 kDa Ro and La) and four small RNAs particles.
- Ben-Chetrit E. Target antigens of the SSA/Ro and SSB/La system. Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):256-8. (PubMed) The SSA/Ro and SSB/La antigens are polypeptides which serve as autoantigens in systemic lupus erythematosus and Sjogren’s syndrome. The SSA/Ro contains two major isoforms of 60 kD and 52 kD. The former is the main native antigen while the latter is a major autoantigen in its denatured form. The SSB/La is a single phosphorylated protein of 48 kD.
- Elaine L. AlexanderThomas T. Provost. Ro (SSA) and La (SSB) antibodies. Springer Seminars in Immunopathology September 1981, Volume 4, Issue 3, pp 253–273
残念ながら根本的にシェーグレン症候群を治癒させることはできません。乾燥症状に対しては症状を軽くすること、他の臓器障害に対してはそれらを抑えることを目的とした治療を行います。(シェーグレン症候群 (Sjögren’s syndrome: SS) しぇーぐれんしょうこうぐん KOMPAS 慶応義塾大学 医療・健康情報サイト)
- シェーグレン症候群 Sjögren’s syndrome,SjS (順天堂大学医学部 膠原病・リウマチ内科)
- シェーグレン症候群の臨床~シェーグレン症候群は最も身近な膠原病~ 2004年
シェーグレン症候群を罹患した著名人
- 和田アキ子が告白した難病「シェーングレン症候群」の怖さ (2011.03.03 16:00 女性セブン / livedoor NEWS) 和田アキ子(60)が2月26日、自身のラジオ番組で、シェーグレン症候群にかかっている可能性があることを告白した。翌27日放送の『アッコにおまかせ!』(TBS系)では、「大丈夫。寝込むほどの病気じゃないから」と語っていたが、実はこの病気、東京都などの自治体が指定する難病のひとつだ。
- 菊池桃子 離婚前から難病「シェーグレン症候群」を患っていた (2012.3.2 10:58週刊朝日 AERAdot.) 1月28日、プロゴルファーの西川哲(43)と17年続いた結婚生活にピリオドを打ったことを発表した菊池桃子(43)。中学3年と小学4年の子どもを抱え、今後は女優業に本格復帰すると思われていた……。 そんな矢先に衝撃的なニュースが飛び込んできた。 離婚をする以前から菊池が難病に苦しんでいたというのだ。 本誌の取材によると、菊池が患った病は「シェーグレン症候群」。
臨床医のための 臨床研究テーマの見つけ方
臨床研究を行う理由
T医師が漠然と感じているような疑問は、臨床に携わっていると日常的に沸き起こってくるはずです。…
「臨床研究」とは、このような漠然とした疑問を、検証可能な「リサーチクエスチョン」として構造化させ、科学的な手法を用いて解決していく過程です。そして疑問を解決していく中で、また新たなリサーチクエスチョンが生まれて来る。そのような連鎖が、臨床医学を前へと進める推進力であり、臨床研究のだいご味です。(臨床研究者育成プログラムのご紹介 東京大学医学部)
病気を深く知ろうとする行為そのものが研究であると考えれば、よい臨床医になるためには研究という作業が必ず伴うのではなかろうか。(京都大学大学院医学研究科・医学部 皮膚科学 教授エッセイ)
臨床研究テーマの見つけ方
臨床研究の大きな流れとしては、まず「後向き研究」からスタートして糸口をつかみ、「前向き研究」の「観察研究」で方向性を定め、さらに「介入研究(臨床試験)」で確認する、というのが王道ですね。…
こうした疑問点をガイドラインなどで調べても、エビデンスがはっきりしない場合がしばしばあります。こういう時こそ問題解決の一つのチャンスなので、さあ後向き研究をやろう、となるわけです。…
後向き研究をやってみると、何かしら解決すべき問題が出てきて、これを前向きに調べることになります。そこまでやると、自分のテーマとしてこれを突き詰めたくなる。(インタビュー第6回:神山 圭介 教授 「治験」と「臨床研究」の違い 慶応義塾大学病院臨床研究推進センター)*太字強調は当サイト
書籍
- 実践対談編 臨床研究立ち上げから英語論文発表まで最速最短で行うための極意 (すべての臨床医そして指導医にも捧ぐ超現場型の臨床研究体験書) 2018/4/18 原 正彦
- 臨床研究立ち上げから英語論文発表まで最速最短で行うための極意 (すべての臨床医に捧ぐ超現場重視型の臨床研究指南書) 2017/12/4 原 正彦
『臨床研究 英語論文 最速最短』は臨床医に研究を勧めて、実際にアイデアの出し方から論文アクセプトに至るまでの道のりをガイドしてくれる本なのですが、基礎研究しか知らない自分が読んでも非常に面白く、大変役立つ内容でした。自分の研究の一番のブレーキになる上司とのかかわり方であるとか、論文原稿を教授が何か月も放置して読んでくれないときにどうすべきかなど、研究者がしばしば遭遇する困難への対処方法、実践的なアドバイスが満載です。
参考
- 臨床研究:実戦的基礎知識 国立国際医療研究センター「初期臨床で身につけたい臨床研究のエッセンス」Vol.2 第4章より抜粋・改変
- Douglas A. Mata. Once You’ve Found the Question: How to Take the Next Steps in Research Nov 08, 2017 (NEJM Resident 360)
- Sadaf Aslam and Patricia Emmanuel. Formulating a researchable question: A critical step for facilitating good clinical research. Indian J Sex Transm Dis AIDS. 2010 Jan-Jun; 31(1): 47–50. PMC3140151 step-by-step guidance on the formulation of a research question
- David A. Katzka. How to Balance Clinical Work and Research in the Current Era of Academic Medicine. Gastroenterology. November 2017; Volume 153, Issue 5, Pages 1177–1180.
皮膚は怪我の後、どうやって治癒していくのか?メカニズムの解説
怪我をして皮膚を切ったりしたときに、人間の体はどのようにして傷を修復するのでしょうか?下の動画が非常にわかりやすく説明してくれます。
創傷が治癒する過程
ケガはどのように治るのか? - サルタック・シンハ 2014/11/11 TED-Ed
Stages of Wound Healing Process 2014/09/28 usmlesteps123
傷の修復過程で線維芽細胞(Fibroblasts)が傷のところに集まってきますが、その過程を模倣した実験観察の動画(下)。
Wound Repair and Fibroblast Migration 2016/09/19 Zar
心室中隔欠損症(Ventricular Septal Defect, VSD)の手術
心室中隔欠損症(Ventricular Septal Defect, VSD)の手術
Ventricular Septal Defect (VSD) Surgical Repair – Pediatric Heart Surgery 2008/08/20 Nicklaus Children’s Hospital
2019年度ノーベル化学賞はリチウムイオン電池の発明者 吉野彰、ジョン・グッドイナフ、スタンリー・ウィッティンガムの3氏に
2019年度ノーベル化学賞受賞者の発表
吉野彰氏の記者会見
ノーベル化学賞の旭化成・吉野彰氏「リチウムイオン電池が受賞してうれしい」(2019年10月9日 THE PAGE ザ・ページ)
吉野彰氏の略歴:
1966年 – 大阪府立北野高等学校卒業
1970年 – 京都大学工学部石油化学科卒業
1972年 – 京都大学大学院工学研究科石油化学専攻修士課程修了
1972年 – 旭化成工業株式会社(現旭化成株式会社)入社
(参照:ウィキペディア)
リチウムイオン電池の誕生
2018 Japan Prize Commemorative Lecture: Dr. Akira Yoshino 2018/04/23 JapanPrize
16S rRNAのシーケンシングによる細菌の種類の同定
Detection and identification of bacteria in clinical samples by 16S rRNA gene sequencing:comparison of two different approaches in clinical practice
https://www.microbiologyresearch.org/docserver/fulltext/jmm/61/4/483_jmm030387.pdf?expires=1570540556&id=id&accname=guest&checksum=5420BE74E3BA950EA45B92F013CBE211
Efficient Nucleic Acid Extraction and 16S rRNA Gene Sequencing for Bacterial Community Characterization
https://www.jove.com/video/53939/efficient-nucleic-acid-extraction-16s-rrna-gene-sequencing-for
Using a 16S rRNA Sequence to Identify a Bacterial Isolate (2017/10/03 Oxford Academic (Oxford University Press))
What Is 16s rRNA sequencing? (2018/08/01 CD Genomics)
https://www.youtube.com/watch?v=3UHiveJ1jzM
2019年度ノーベル物理学賞受賞者はJames Peebles, Michel Mayor , Didier Queloz の3氏に
2019年度ノーベル物理学賞の授与
8 October 2019
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2019
“for contributions to our understanding of the evolution of the universe and Earth’s place in the cosmos” with one half
to James Peebles Princeton University, USA
“for theoretical discoveries in physical cosmology” and the other half jointly
to Michel Mayor University of Geneva, Switzerland
and Didier Queloz University of Geneva, Switzerland University of Cambridge, UK
“for the discovery of an exoplanet orbiting a solar-type star” (nobelprize.org)
2019年度ノーベル物理学賞発表の様子
Announcement of the Nobel Prize in Physics 2019
参考
- New perspectives on our place in the universe (Nobelprize.org)
- Scientific Background on the Nobel Prize in Physics 2019 PHYSICAL COSMOLOGY AND AN EXOPLANET ORBITING A SOLAR-TYPE STAR (Nobelprize.org)
低酸素、腎臓、hypoxia-inducible factor (HIF) 、エリスロポエチン(Epo)について
2019年度ノーベル医学生理学賞は、低酸素刺激に対して生体がどのように反応するかに関する研究を行ったウィリアム・ケリン、ピーター・ラトクリフ、グレッグ・セメンザの3氏に贈られました。
hypoxia-inducible factor (HIF) の発見
HIF-1は,肝がん細胞株 Hep3B において「低酸素依存的 にエリスロポエチン(EPO)を誘導する因子」として1992 年に Semenza らによって発見された.
Semenza, G.L. & Wang, G.L.(1992)Mol. Cell. Biol., 12, 5447―5454.
エリスロポエチン(Epo)
エリスロポエチン(Epo)は赤血球産生を制御する造血ホルモンであり、組織の低酸素に応答して産生され、骨髄などの造血細胞に働いて赤血球産生を刺激します(図2)。高地トレーニングをしている運動選手の血液では赤血球数、および、酸素運搬に関わるヘモグロビン量が増加しますが、これも低酸素環境におけるEpo産生の亢進によるものです。また、ヒトの大人ではEpoは主に腎臓において産生されます。(引用元:エリスロポエチン遺伝子の発現制御 dmbc.med.tohoku.ac.jp)
腎臓と低酸素
腎臓は酸素消費が多く,更に動静脈シャントのため 酸素の取り込み効率が悪いため,低酸素状態になりや すい臓器であり,様々の要因によって引き起こされる 尿細管間質の慢性低酸素が腎臓病の final common pathway として注目されている。(引用元:日児腎誌 Vol. 25 No. 2)
腎臓は生体が必要とする酸素の30%を消費する,非常に酸素需要の高い臓器となっている.このため,腎臓病のfinal common pathwayとして,尿細管間質の慢性低酸素状態が特に重要と考えられている.(第 113 回日本内科学会講演会 結実する内科学の挑戦~今,そしてこれから~ 平成28年4月17日(日)東京都・東京国際フォーラム 日本内科学会雑誌 105 巻 9 号)
腎が低酸素になりやすい理由としては,エネルギー需要が高いことに加え,尿細管周囲毛細血管網による酸素供給が血行動態の変化により影響を受けやすいことや,解剖学的な理由により動静脈酸素シャントが存在するため酸素の利用効率が悪いことがあげられる.(慢性低酸素状態の腎臓 244巻4号 2013年1月26日 医学のあゆみ)
HIF刺激薬
EPO遺伝子の転写を促進する低酸素誘導因子(hypoxia-inducible factor: HIF)が同定され、さらにその上流の調節機構が解明されたことを背景に、「HIF活性化薬」としてPHD阻害薬が開発されました。 PHDはHIF (α鎖)を水酸化し、ユビキチン・プロテアソーム分解を導く酵素で、PHDの酵素活性を阻害するとHIFは安定化し、HIFを介する低酸素応答が誘導されます。(第4回(1)EPOから生まれた「HIF刺激薬」ここがすごい!執筆:田中哲洋(東京大学医学部附属病院)、監修:南学正臣(東京大学医学部附属病院)2018年8月15日 m3.com)
2019年ノーベル医学生理学賞はウィリアム・ケリン、ピーター・ラトクリフ、グレッグ・セメンザの3氏に
2019年ノーベル医学生理学賞はウィリアム・ケリン、ピーター・ラトクリフ、グレッグ・セメンザの3氏に贈られました。
The Nobel Assembly at Karolinska Institutet
has today decided to award
the 2019 Nobel Prize in Physiology or Medicine
jointly to
William G. Kaelin, Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza.
for their discoveries of how cells sense and adapt to oxygen availability (PDF)
2019年ノーベル医学生理学賞発表の瞬間
Announcement of the Nobel Prize in Physiology or Medicine 2019 Nobel Prize
Sir Peter J. Ratcliffe
ノーベル賞受賞直後のピーター・ラトクリフ氏の電話インタビュー
ピーター・ラトクリフ博士の講演動画。
Elucidation of oxygen sensing pathways in human and animal cells // Peter Ratcliffe 2018/09/28 The Physiological Society
William G. Kaelin
ウィリアム・ケリンのレクチャー動画。
Signaling Pathways in Cancer Symposium: William Kaelin 2016/08/11 KochInstituteMIT
Gregg Semenza
グレッグ・セメンザ(Gregg Semenza)が語る研究者の日常、研究はいかに進むか。
Gregg Semenza on the discovery of HIF-1
下の動画は、生い立ちから研究の話までのロング・インタビュー。
JCI’s Conversations with Giants in Medicine: Gregg Semenza 2016/11/02 Journal of Clinical Investigation
参考
- Scientific Background How cells sense and adapt to oxygen availability (nobelprizemedicine.org)
- ノーベル医学生理学賞に米、英の3氏 「細胞の低酸素応答の仕組みの解明」(201/10/7(月) 18:42 毎日新聞 YAHOO!JAPAN) スウェーデンのカロリンスカ研究所は7日、2019年のノーベル医学生理学賞を米国とイギリスの3氏に授与すると発表した。受賞理由は「細胞の低酸素応答の仕組みの解明」。 受賞が決まったのは、米ハーバード大のウィリアム・ケリン教授▽英オックスフォード大のピーター・ラトクリフ教授▽米ジョンズ・ホプキンズ大のグレッグ・セメンザ教授。
RECIST(レシスト)、mRECIST
RECIST
- 固形がんの治療効果判定のための新ガイドライン (RECIST ガイドライン) ー 改訂版 version 1.1ー 日本語訳 JCOG 版 ver.1.0
- 固形がんの治療効果判定のための 新ガイドライン (RECIST ガイドライン) ―日本語訳 JCOG版―
国際標準の治療効果判定規準である RECIST(Response Evaluation Criteria in Solid Tumors)guidelines がその妥当性ならびに従前のWHO 規準との再現性から、2000年に固形がん治療効果判定の国際標準として認知されている。RECIST は 2009 年
に EORTC(European Organization for Research and Treatment of Cancer)より改定された(E.A. Eisenhauer, et al. Eur J Cancer 2009;45:228-47)。(20-15 画像によるがんの診断、治療法選択、治療効果判定に関する研究)
mRECISTとは
2010年に Lencioni らによって提唱された modified RECIST(mRECIST)は,早期濃染 部の径を測定することで肝癌治療効果判定に血流評価を加えた新しい基準である.(肝臓 53 巻 3 号 147―154(2012))
一般的に固形癌の治療効果判定基準として WHO 基準を簡略化した Response Evaluation Criteria in Solid Tumors version1.1(RECIST1.1)が用いられている.しかしながら,肝細胞癌の治療においては,腫瘍壊死を治療効果として考えることが一般的であり,腫瘍壊死を効果判定基準に考慮されていない RECIST1.1 は問題があるとされている.一方,肝細胞癌の治療効果判定基準として腫瘍壊死を考慮に入れた modified(m)RECISTと日本肝癌研究会による肝癌治療直接効果判定基準 Response Evaluation Criteria in Cancer ofthe Liver(RECICL)も使用されている.mRECISTと RECICL でも 1 方向測定と 2 方向測定で明らかな違いがあり,その実用性,有用性については議論が分かれている.(肝臓 53 巻 6 号 344―347(2012))
- Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010 Feb;30(1):52-60. doi: 10.1055/s-0030-1247132. Epub 2010 Feb 19.
- New Data Supporting Modified RECIST (mRECIST) for Hepatocellular Carcinoma. Riccardo Lencioni. Clinical Cancer Research 2013
Dr. Lencioni on Assessing Response to HCC Therapy 2018/09/16
複数のタイムポイントの測定値と開始点との個別の比較 多重比較の問題
例えば、薬物投与前後で差があるかどうかを調べるために経時変化を追う実験を行ったとします。どの時刻で開始時刻(薬物投与前)と差が出るかを調べるために、複数のデータポイントの各々と測定開始時とをペアワイズに比較することにして、2群間の比較でよく使うt-検定やWilcoxon検定を単純に適用してよいものでしょうか?たまに、そのような解析をした論文をたまに見かけることがありますが、これは非常に初歩的な、統計の誤用だと思われます。
データを入力するだけで統計ソフトが出力を返してくれるので、適用する検定方法が間違っていたとしても、P値だけは簡単に得ることができてしまいます。その結果、有意差がないデータに有意差を見出して論文報告してしまう危険があるので、要注意です。
経時データ(反復測定値)の統計学的解析における誤用の多さ
鍼灸研究における統計誤用が多発しているため、この経時測定データの解析法について調べても、ほとんど誤用といってよい(経時測定データの解析法 七堂利幸)
多群間の平均値の比較において,その目的に応じた多重比較法を用いることが一般化してきた.しかしながら,経時データのように複数の測定時点がある場合に,時点ごとに多重比較法を繰り返し適用することは,いずれかの時点で有意な差が出やすくなる「時点の多重性の問題」が新たに生じてしまう.(引用元:日薬理誌133,325~331(2009))
比較試験では各被験者について経時的に種々の評価や測定がなされ、経時的な薬効差の検討が行われる。この際の検定に当っては、薬剤群ごとに処置開始時点とそれ以降の評価時点とに対応のある場合の検定を繰返したり、各時点とに2群間での対応のない場合の検定を繰しがちであるが、それでは第1種の過誤の確率の増大する。(引用元:臨床試験の統計解析に関するガイドライン 平成4年3月4日)
経時データ(反復測定値)の統計学的解析に関する現状
一般に用量時間反型データに繁用されている統計解析は2種類ある.一っは「輪切り」検定であり,他の一っは2元配置分散分析である.(薬理試験における統計解析のQ&A 反復測定データの解析法への一提案 吉村功、大森崇 日薬理誌110、333~340(1997))
経時データ(反復測定値)の推奨される解析方法
13.経時的比較
比較試験では各被験者について経時的に種々の評価や測定がなされ、経時的な薬効差の検討が行われる。この際の検定に当っては、薬剤群ごとに処置開始時点とそれ以降の評価時点とに対応のある場合の検定を繰返したり、各時点とに2群間での対応のない場合の検定を繰しがちであるが、それでは第1種の過誤の確率の増大する。このようなデータの場合には時点毎の比較ではなく、トレンドやプロフィルを比較するための特別な手法が必要である。
(引用元:臨床試験の統計解析に関するガイドライン 平成4年3月4日 http://home.att.ne.jp/red/akihiro/Old_stat_guideline_Japanese.pdf)
- 臨床試験のための統計的原則 医薬審 第1047号 平成10年11月30日 各都道府県衛生主管部(局)長 殿 厚生省医薬安全局審査管理課長 本ガイドラインは、本通知の日以降施行し、これに伴い、「臨床試験の統計解析に関するガイドライン(平成4年3月4日薬新薬第20号)」(以下「旧ガイドライン」という。)は廃止する。
慢性疾患のための治療の研究で、経時的に機能の状態を評価する場合も、主要変数の選択に関して別の問題が生じる。可能な対処法としては、観察期間の最初と最後になされた評価の比較、全期間を通じたすべての評価から求めた傾きの比較、定めた閾値を超える若しくは下回る被験者の割合の比較、又は繰り返し測定データのための方法に基づいた比較といった多くのものがある。(引用元:2.2.2 主要変数と副次変数 臨床試験のための統計的原則 医薬審 第1047号 平成10年11月30日) *太字強調は当サイト
下は、なんでもかんでも検定して有意差を出せばよいと思っている人に対する警告。
では両者に共通な問題点は何だろうか.それは実験で知りたいことが反応の時間曲線であり,それが用量によってどうわるかであるのに,それに答えられるはずのない「検定という形式」の統計解析を行っていることである.ここで採用している検定という形式は,「反応が用量によって変わらない」あるいは,「反応が時間によって変わらない」という仮説が,実際に測定したデータから否定できるかどうかを判定するものである.だからそれによって得られる結論は,「反応が用量によって変わるところがあるかどうか」,あるいは「反応が時間によって変わるところがあるかどうか」ということでしかない.(薬理試験における統計解析のQ&A 反復測定データの解析法への一提案 吉村功、大森崇 日薬理誌110、333~340(1997))*太字下線強調は当サイト
参考
- 薬理試験における統計解析のQ&A 反復測定データの解析法への一提案 吉村功、大森崇 日薬理誌110、333~340(1997)一般に用量時間反型データに繁用されている統計解析は2種類ある.一っは「輪切り定」であり,他の一っは2元配置分散分析である.
- 改訂増補版:統計検定を理解せずに使っている人のためにIII 池田 郁男 東北大学未来科学技術共同研究センター Published: 2019-10-01 © 2019 公益社団法人日本農芸化学会 ”たとえば,0分と5分後の2点の比較であれば,paired t testを行うことができる.しかし,ここでは4点あるので,paired t testは使えない.分散分析は何らかの変化が起こったことがわかるので,この例では有意差が得られれば,統計的に有意に増加が起こったと判断される.”
- 保健・医療研究の進め方入門 —R と EZR を用いて— (保健学共通特講 IV, VIII テキスト Rev. 0.9.9.4) 神戸大学大学院保健学研究科教授:中澤 港 2019 年 7 月 24 日 第 12 章 反復測定データの解析
- 薬理学研究における経時データ解析の考え方─血圧降下試験事例による解説─ 高橋 行雄 日薬理誌(Folia Pharmacol. Jpn.)133,325~331(2009)
- 経時データの多重比較法 岸本 淳司 (SAS/慶應義塾大学/東京大学)
- 反復測定分散分析 Repeated-Measure Analysis of Variance (ANOVA) オーエムエス出版
- 多群・経時データの解析と多重比較 医学統計セミナー アドバンスコース 下川 敏雄 和歌⼭県⽴医科⼤学 臨床研究センター(スライドPDF)
- 経時的繰り返し測定データの解析 医学統計勉強会 東北大学病院循環器内科・東北大学臨床研究推進センター 共催 東北大学大学院医学系研究科EBM開発学寄附講座 宮田 敏 2013/10/31 第6回
- Bretz et al. (2011). Multiple Comparisons Using R.
- 基本的な回帰モデル • 混合モデル • 「混合モデル」手法の別例 • 反復測定の例 JMP13.2 オンラインマニュアル
- 臨床試験における多重性の諸問題 計量生物学 Vol. 36, Special Issue, S 87–S 98 (2015) 寒水孝司 東京理科大学工学部経営工学科
- 臨床試験における統計的諸問題 明星大学・理工学部 広津 千尋 数理解析研究所講究録 1273 巻 2002 年 78-86
- 経時測定データの解析法ーその文献とソフトの紹介ー 七堂利幸 鍼灸研究における統計御用が多発しているため、この経時測定データの解析法について調べても、ほとんど御用といってよい
- 生物医学研究文献の誰でも見つけられる20の統計学的誤り Tom Lang
- ウィルコクソンの順位和検定とは?t検定との違いは?(一番優しい、医薬品開発に必要な統計学の教本)
- 連載 第 2 回 医学データの統計解析の基本 2 つの平均の比較 朝倉こう子・濱﨑俊光 t検定は日常的に利用されるが、実際のデータ解析 でのt検定の利用について、「観測値数が極端に少ない場合、t検定は適用可能か(観 測値数がどの程度あればt検定が適用可能か)」、「観測値の正規性の検定をしたとこ ろ、正規分布に従わないとの結果が得られたから、t検定の代用としてWilcoxonの 順位和検定(あるいはMann-WhitneyのU検定)を用いたが、この判断に間違いない か」、「統計手法の手順書には、2つの群でデータの分散の大きさが異なる場合には、t 検定の代用としてWelchのt検定を適用すべきとの記載があったが、2つの群の分散 が異ならない場合にもWelchのt検定は適用可能か」といった疑問をよく耳にする。
- 毒性試験および生物を扱う研究者のための統計解析 小林 克己
細胞傷害性T細胞(キラーT細胞)とは
細胞傷害性T細胞とは
細胞傷害性T細胞(cytotoxic T lymphocyte; CTL)は、リンパ球T細胞の一種で、宿主にとって異物である細胞すなわち、移植細胞、ウイルス感染細胞、癌細胞などを認識して破壊する。(参照:ウィキペディア)
細胞傷害性T細胞の呼称
細胞傷害性T細胞は、キラーT細胞、CD8陽性T細胞、CD8+T細胞などとも呼ばれる。(参照:ウィキペディア)
細胞傷害性T細胞の分化
未分化のT細胞は、CD4分子と、CD8分子の両方を発現している(ダブルポジティブ)。T細胞が成熟するにつれ、分化をしていき、CD4とCD8のどちらか一方しか発現しなくなる(シングルポジティブ)。CD8分子を発現しているT細胞がキラーT細胞へと分化する。他方、CD4分子を発現しているT細胞はヘルパーT細胞へ分化する。(参照:ウィキペディア)
細胞傷害性T細胞の活性化
抗原刺激を受ける前のキラーT細胞は、細胞傷害活性を持たないナイーブCD8陽性T細胞であるが、抗原刺激を受けを受けて活性化し、細胞傷害活性を持つようになる。(参照:ウィキペディア)
細胞傷害性T細胞の活性化のしくみ
抗原提示細胞(APC)が、ナイーブCD8陽性T細胞に対して、異物の「抗原ペプチド」(ウイルスや細菌などの抗原を分解したペプチドのこと)クラスI主要組織適合抗原(MHC-class I)と共に提示する。ナイーブCD8陽性T細胞は、T細胞受容体(TCR; T cell receptor)を介してそれを認識する。これと同時に「共刺激分子」からのシグナルが入っていると(後述)、ナイーブCD8陽性T細胞はこの異物の抗原ペプチドを提示する細胞に特異的な細胞傷害活性を持つようになる。(参照:ウィキペディア)
共刺激
- T細胞活性化におけるCD137受容体の役割 (Immuno-Oncoloy)
- T細胞の活性化 (Immuno-Oncology)
殺すべき細胞をキラーT細胞が認識する仕組み
ほとんどの細胞は、細胞表面にMHC(主要組織適合性複合体)クラスIという分子を持っていて、普段はMHCクラスIの上に自分自身の抗原をを乗せて細胞表面に提示している。この「目印」のおかげで、キラーT細胞からの攻撃を受けずにすんでいる。しかし、細胞が病原体に感染すると、MHCクラスIの上に(自分自身の抗原ではなく)病原体由来の抗原を乗せて細胞表面に提示する。これが目印となり、病原体に感染した細胞はキラーT細胞に殺傷される。(参照:理研プレスリリース解説 平成28年)
病原体や癌細胞の抗原がT細胞に認識される様子をまとめた下の図がわかりやすい。

(出典:京府医大誌 126(6),377~389,2017)
キラーT細胞が相手の細胞を殺す仕組み
CTLは細胞傷害物質であるパーフォリン、グランザイム、 TNF (tumor necrosis factor)などを放出したり、ターゲット細胞のFasを刺激してアポトーシスに陥らせることで異物を攻撃する。(参照:ウィキペディア)
キラー細胞が標的細胞を認識すると細胞間隙にパーフォリンやグランザイムBなどを含む顆粒成分が放出される.また, キラー細胞表面上に発現したFasL, TRAIL,TNF-α,TWEAKといったTNFファミリー分子が標的細胞上に発現している各々の対応するレセプターに結合することによって,標的細胞に細胞死が誘導される.(Inflammation and Regeneration Vol.23 No.3 May 2003 PDF)