原因は、不適切な刺激方法によるものと、心因性のものとの2群に大別できる。… 外来を訪れた膣内射射精患者265名中、不適切な刺激方法によるもの(シーツや畳にこすりつける、大腿部に挟んで腹圧をかけるなどの非用手的マスターベーション、強すぎるグリップなど)の射精障害患者は176名(66%)にも及んでいる。(膣内射精障害患者に対するマスターベーションエイドを用いた射精リハビリテーション 獨協医科大学越谷病院泌尿器科 日本泌尿器科学会雑誌The Japanese Journal of Urology VOl.103 No.3 May 2012 PDFJ-STAGE)
I never believed you could feel implantation until I did with my second pregnancy. I was snorkelling at the time so very aware of my body in the water. For me it was just like 10 seconds of a very localised sharpish pain in my lower abdomen/pubic bone region. I just knew straightaway what it was and sure enough 5 days later when I got home from the holiday I got a BFP. (09/08/14 Highschoolsweetheart What does implantation pain feel like? babycenter.com.au)
Once the blastocyst reaches the uterus, it implants into the uterine lining. This process is known as implantation and can often cause what are called implantation cramps. (Implantation Cramping: How Long Does It Last? When Should I Worry? December 2, 2018 Medically Reviewed by Christine Traxler, MD, BS MomLovesBest.com)
First gene-edited babies reported in China (Associated Press2018/11/25 に公開)
HONG KONG (AP) — A Chinese researcher claims that he helped make the world’s first genetically edited babies — twin girls born this month whose DNA he said he altered with a powerful new tool capable of rewriting the very blueprint of life. If true, it would be a profound leap of science and ethics. (Chinese researcher claims first gene-edited babies
By MARILYNN MARCHIONE November 26, 2018 AP)
He Jiankui副教授は、ヒトゲノム編集国際会議の2日目(28日)の午前中のセッションHuman Embryo Editingに登壇し研究成果を発表しました。
11:30 a.m.
Human Embryo Editing
Moderator:
Robin-Lovell-Badge,* The Francis Crick Institute
Speakers:
Kathy Niakan, The Francis Crick Institute
Paula Amato, Oregon Health & Science University
Maria Jasin, Memorial Sloan Kettering Cancer Institute
Xingxu Huang, Shanghai Tech University
Jiankui He, Southern University of Science and Technology
(引用元:SECOND INTERNATIONAL SUMMIT ON HUMAN GENOME EDITING AGENDA)
下の動画で1:15:30~からが、Jiankui He博士によるプレゼンテーションです。今回の騒動を受けて、司会者が予めに観客に静かに最後まで聴くようお願いしています。また、今回のゲノム編集ベビー誕生はもともとJiankui He博士が事前に提出していた講演資料には存在していなかったものであり、「ヒトゲノム編集国際会議」としては全く知らなかったことであると説明しています。そして、Jiankui He博士に説明の機会を与えようと述べて、演者を登場させました(Jiankui He博士の登壇は、動画1:17:53~)。講演タイトルは、CCR5 gene editing in mouse, monkey and human aembryos using CRSPR/Cas9 です。
His sperm has been used to create 36 children: 19 boys and 17 girls from 26 families
Chris Aggeles, a now 39-year-old man from Georgia, has struggled with serious mental illness for much of his adult life. In addition to schizophrenia, court documents show he has had diagnoses of bipolarandnarcissistic personality disorders, and has described himself as having schizoaffective disorder.
He has a history of run-ins with the law, has done time in jail, dropped out of college and struggled in the past to hold down jobs. (He was the perfect sperm donor. Then 26 families found out he wasn’t By THERESA BOYLEHealth Sat., April 9, 2016 THE STAR)
Sperm bank’s ‘perfect donor’ was a mentally ill felon who fathered 36 kids (Rob Quinn 11:00 a.m. ET April 15, 2016 | USA TODAY)
ABSTRACT Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISPR/Cas9 in human pre-implantation embryos. In this report, we used tripronuclear (3PN) zygotes to further investigate CRISPR/Cas9-mediated gene editing in human cells. We found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB). However, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic. Off-target cleavage was also apparent in these 3PN zygotes as revealed by the T7E1 assay and whole-exome sequencing. Furthermore, the endogenous delta-globin gene (HBD), which is homologous to HBB, competed with exogenous donor oligos to act as the repair template, leading to untoward mutations. Our data also indicated that repair of the HBB locus in these embryos occurred preferentially through the non-crossover HDR pathway. Taken together, our work highlights the pressing need to further improve the fidelity and specificity of the CRISPR/Cas9 platform, a prerequisite for any clinical applications of CRSIPR/Cas9-mediated editing. (http://link.springer.com/article/10.1007/s13238-015-0153-5/fulltext.html)
PROTEIN & CELL誌を発行しているのはシュプリンガー(Springer)社ですが、チーフエディターが中国の人で、他のエディターも5人中4人が中国、ボードメンバーも66人中26人が中国の人です。また、この雑誌は通常の学術論文を掲載するだけでなく、特に、
Presents research highlights, news and views, and commentaries covering research policies and funding trends in China (http://www.springer.com/life+sciences/biochemistry+%26+biophysics/journal/13238)
中国の研究動向を取り上げる方針を持っており、さらに、オープンアクセスのための論文掲載費用は、
Protein & Cellis a peer-reviewed open access journal published monthly. The open access fees (article-processing charges) for this journal are kindly sponsored by Higher Education Press, Beijing Institutes of Life Science, Chinese Academy of Sciences and Biophysical Society of China. Authors can publish in the journal without any additional charges.(http://www.springer.com/life+sciences/biochemistry+%26+biophysics/journal/13238)
First experiment ‘editing’ human embryos ignites ethical furor (Reuters Apr 23, 2015):”Biologists in China reported carrying out the first experiment to alter the DNA of human embryos, igniting an outcry from scientists who warn against altering the human genome in a way that could last for generations.”