Kim et al. Nature 15 October 2009

Kim et al. DNA demethylation in hormone-induced transcriptional derepression. Nature 461, 1007-1012 (15 October 2009)


2008年8月18日 論文投稿
2009年8月24日 論文受理
2011年11月1日 論文訂正
2012年6月14日 論文撤回


DNA demethylation in hormone-induced transcriptional derepression

Mi-Sun Kim1,2,3, Takeshi Kondo2, Ichiro Takada2, Min-Young Youn2, Yoko Yamamoto2, Sayuri Takahashi2, Takahiro Matsumoto1,2, Sally Fujiyama1,2, Yuko Shirode1,2, Ikuko Yamaoka1,2, Hirochika Kitagawa2, Ken-Ichi Takeyama2, Hiroshi Shibuya3, Fumiaki Ohtake1,2 & Shigeaki Kato1,2

  1. ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan
  2. Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
  3. Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Correspondence to: Shigeaki Kato1,2 Correspondence and requests for materials should be addressed to S.K. (Email:

Nature 461, 1007-1012 (15 October 2009) | doi:10.1038/nature08456; Received 18 August 2008; Accepted 24 August 2009

There is a Corrigendum (1 December 2011) associated with this document.

There is a Retraction (14 June 2012) associated with this document.


Several lanes of the ChIP analyses in this Letter were inadvertently duplicated or erroneously created during figure assembly. We now provide corrected figure panels for Figs 1f, 2c, 2f, 2g and 3h and Supplementary Figs S8, S9a, S9b, S11, S13b, S18 and S28. Our results and conclusions are not affected by these errors, but we apologise for the careless mistakes made.

During initial preparation of the figure panels, the panels for the negative controls (with no obvious signals), inputs and some data were inappropriately duplicated and mixed up. The experiments were performed several times, so a set of data with adequate negative controls and inputs from one experimental round could be found. We have replaced the previous set of data in these panels with a correct set, and confirmed that these corrections do not affect the original claims in the published text. Representative ChIP data are displayed and significance was statistically assessed from several independently repeated experiments. We have also repeated the experiments and obtained the same results as those in the published figures.

In this Letter, we claimed that hormone-regulated transcriptional control involves DNA demethylation mediated by MBD4. Subsequently, we corrected some figure panels that appeared to have been erroneously prepared (Corrigendum, However, we later found that other figure panels contained data duplications. After further review, we now conclude that the results presented in the original figures had been inappropriately manipulated, and given these more serious concerns we no longer have confidence in the original figures. We therefore wish to retract this Letter and sincerely apologise for any adverse consequences that may have resulted from the paper’s publication.

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