手段はusingかby usingかbyかwithか?

論文を書いていると、「手段」を表すときの英単語として、using とby usingのどちらを使うべきかでよく迷います。withやbyという選択肢もありますので、さらに迷います。

using? by using? with? by? 何を使えば良いのか、参考になりそうなウェブサイト、書籍、および、論文中の例を紹介します。

‥‥ 「by using」と「using」はいずれも可能ですが、どちらにするかによって文意が微妙に異なります。「by using」によっては、Aを得るのに coupled cluster method だけで十分だというニュアンスが含まれます。(by, using, by using の使い分けについて エナゴ学術英語アカデミー)


(ある行為を描写している文の)動詞が受身形である場合には、byの目的語になりうるのはその行為を行う行為者を表す語のみだということである。つまり、その行為者が利用する道具、手段などがbyの目的語になることはありえない。(科学論文の英語用法百科 第1編 よく誤用される単語と表現 Chapter 29 147ページ)

能動態の場合でも、by の替わりに、(by) using、with、(by) employing、through、in terms of、by applying、(by) utilizing、(by) making use of、through use of、by means of、with the help of、with the aid of、from のような、意味がよりはっきり限定された表現を使用した方が望ましい。(科学論文の英語用法百科 第1編 よく誤用される単語と表現 Chapter 29 147ページ)







  1. The cells were examined by fluorescent microscopy using a Leica SP2 confocal microscope (Leica, Wetzlar, Germany). (doi: 10.1186/1471-2202-13-48 PMC3407521) [Google Scholar “examined by * microscopy” 約 151,000 件]
  2. Cells were examined by confocal microscopy following MitoTracker staining. (10.1371/journal.pone.0015901) [Google Scholar “examined by * microscopy” 約 151,000 件]
  3. These images were obtained by ceiling mounted X-ray sources and corresponding floor mounted amorphous silicon image detectors. (10.3389/fonc.2012.00063) [Google Scholar “obtained by * detector” 約 2,050 件] :


  1. MOR distribution was examined with a Zeiss confocal microscope using a 63× oil immersion objective. (10.1371/journal.pone.0019372) [Google Scholar “examined with * microscope” 約 7,180 件]


  1. All images were acquired using a Zeiss confocal microscope (LSM 510 META DuoScan) (10.1371/journal.pone.0009465)[Google Scholar “acquired using * microscope” 約 1,020 件]

by usingを用いた文例

  1. Living and fixed cells were imaged by using widefield microscopy as previously described. (10.1371/journal.pone.0009898) [Google Scholar “imaged by using * microscopy” 約 140 件 ]




  1. Multiple comparisons were controlled for using the Bonferroni correction (P<0.0005). (10.1038/sj.bjc.6604935) [Google Scholar ” controlled for using” 約 5,890 件]

by usingを用いた文例

  1. Day of the week effects, holidays, and epidemics were controlled for by using dummy variables. (10.1289/ehp.7387)[Google Scholar “controlled for by using” 約 2,770 件 ]



by usingを用いた文例

  1. Our findings underscore the importance of considering HER3 behavior in the context of its molecular environment, which we were able to control by using a cell line that does not endogenously express HER receptors. ( 10.1073/pnas.1617994114) [Google Scholar “by using a cell line” 約 404 件]




  1. To separate the effects of cell cycle perturbation from changes in viral gene expression, we conducted experiments using a cell line that is relatively resistant to profound growth arrest with rapamycin treatment. (10.1371/journal.pone.0014535) [Google Scholar “experiments using a cell line” 約 72 件 ]


『科学論文の英語用法百科 第1編 よく誤用される単語と表現』のChapter 29では、13ページにわたって、日本人が犯しやすいbyの誤用に関する詳細な説明があります。その中の、29.1[行為]+by+[道具]のような表現 29.1.3「道具」が手段、過程、方法、などである場合 というセクションから一つだけ例を紹介します。

誤:This integral was performed by the Newman method.

正:This integral was performed /with/using/ the Newman method.




  1. The intervertebral rotation calculated by our method during an
    extension movement was comparable to the rotation calculated by the manual method for the C2/C3 to C6/C7 segments. (Image Analysis: 20th Scandinavian Conference, SCIA 2017) [Google Scholar “calculated by * method” 約 92,700 件]


  1. The normalized mean number of division that cells have undergone was calculated using method of De Boer and Perelson, where Xn(t)  =  the number of cells undergone n divisions by time t [51]. (10.1371/journal.pone.0015154) [Google Scholar “calculated using * method” 約 44,500 件]


  1. Intraclass correlation coefficients were calculated with the method described by Snijders and Bosker. (10.1136/bmj.b5479) [Google Scholar “calculated with * method” 約 16,600 件]




  1. The level of βGeo expression was analyzed using two methods. (10.1186/1471-2202-11-62)[Google Scholar “was analyzed using * method” 約 5,180 件] [Ludwigh “was analyzed using * method 30 ]


  1. Data was analyzed with Prism 5 (GraphPad software). (10.1186/s12915-015-0167-8) [Google Scholar “data was analyzed with” 約 17,500 件]


  1. Data was analyzed by custom Matlab scripts. (10.7554/eLife.08688) [Google Scholar “data was analyzed by” 約 19,000 件]
  2. Data was analyzed by ∆-∆CT method using 18S ribosomal transcript as endogenous control. (10.1038/s41598-017-12940-0) [Google Scholar “was analyzed by * method” 約 13,300 件] [Ludwig “was analyzed by * method” 2 件]



  1. オンライン言語検索サービスのLudwigで英文をブラッシュアップ (TechCrunch Japan 2016年8月07日) 2016年2月に公開されたLudwigは、正しい英語の文章を書くサポートをする言語検索エンジンだ。(1日15回検索まで無料。それ以上のヘビーユーザーには有料コースあり)
  2. Ludwich (ludwig.guru): We built a gigantic database with millions of correct English sentences and an algorithm specialized in language so that you can compare any of your English phrases with a set of similar correct and contextualized ones.(1日15回検索まで無料。それ以上のヘビーユーザーには有料コースあり)
  3. エナゴ学術英語アカデミー パケット道場~初級アカデミック英語講座~
  4. 科学論文の英語用法百科 第1編 よく誤用される単語と表現 グレン・パケット 著 京都大学学術出版会


科学論文の英語用法百科 第1編 よく誤用される単語と表現
科学論文の英語用法百科 第2編 冠詞用法


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