2014年8月1日の記事も合わせて御覧ください ⇒ 東大分生研加藤茂明研究室の論文不正問題で加藤(元)教授が実験ノート捏造を指示:東京大学科学研究行動規範委員会が結論
科学研究行動規範委員会の調査において、「科学的な適切性を欠いた画像が掲載されていた」とした51報の論文(http://www.u-tokyo.ac.jp/public/pdf/20131226_04-2_appendix1_jp.pdf)。筆頭著者が異なる捏造論文がこれほど大量に出たということは、たまたま血迷った人がいたということではなく、研究室内での組織的な論文捏造と思われます。
- Genes Dev. 2010 Jan 15;24(2):159-70. doi: 10.1101/gad.1857410. Epub 2009 Dec 29. A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, Tanabe M, Zhao Y, Kimura S, Fujiyama S, Ueda T, Umetsu D, Ito T, Takeyama K, Kato S.
-
J Biol Chem. 2009 Nov 20;284(47):32472-82. doi: 10.1074/jbc.M109.009738. Epub 2009 Sep 23.Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.Oya H, Yokoyama A, Yamaoka I, Fujiki R, Yonezawa M, Youn MY, Takada I, Kato S, Kitagawa H.
-
Nature. 2009 Oct 15;461(7266):1007-12. doi: 10.1038/nature08456. DNA demethylation in hormone-induced transcriptional derepression.Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S.
- Mol Cell Biol. 2009 Jan;29(1):83-92. doi: 10.1128/MCB.00884-08. Epub 2008 Nov 3. Coactivation of estrogen receptor beta by gonadotropin-induced cofactor GIOT-4. Kouzu-Fujita M, Mezaki Y, Sawatsubashi S, Matsumoto T, Yamaoka I, Yano T, Taketani Y, Kitagawa H, Kato S.
- Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3818-22. doi: 10.1073/pnas.0809819106. Epub 2009 Feb 23. Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Suzuki E, Zhao Y, Ito S, Sawatsubashi S, Murata T, Furutani T, Shirode Y, Yamagata K, Tanabe M, Kimura S, Ueda T, Fujiyama S, Lim J, Matsukawa H, Kouzmenko AP, Aigaki T, Tabata T, Takeyama K, Kato S.
- Genes Cells. 2007 Nov;12(11):1281-7. A reduction state potentiates the glucocorticoid response through receptor protein stabilization. Kitagawa H, Yamaoka I, Akimoto C, Kase I, Mezaki Y, Shimizu T, Kato S.
- Nat Cell Biol. 2007 Nov;9(11):1273-85. Epub 2007 Oct 21. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S.
- Mol Cell Biol. 2007 Jul;27(13):4807-14. Epub 2007 Apr 30. The pituitary function of androgen receptor constitutes a glucocorticoid production circuit. Miyamoto J, Matsumoto T, Shiina H, Inoue K, Takada I, Ito S, Itoh J, Minematsu T, Sato T, Yanase T, Nawata H, Osamura YR, Kato S.
- Mol Cell Biol. 2007 Nov;27(21):7486-96. Epub 2007 Aug 20. A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling. Kitagawa H, Ray WJ, Glantschnig H, Nantermet PV, Yu Y, Leu CT, Harada S, Kato S, Freedman LP.
- J Biol Chem. 2006 Jan 6;281(1):20-6. Epub 2005 Oct 31. An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. Oishi H, Kitagawa H, Wada O, Takezawa S, Tora L, Kouzu-Fujita M, Takada I, Yano T, Yanagisawa J, Kato S.
- Mol Cell Biol. 2007 Nov;27(22):7947-54. Epub 2007 Sep 17. Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Igarashi M, Yogiashi Y, Mihara M, Takada I, Kitagawa H, Kato S.
- J Pharmacol Exp Ther. 2005 Nov;315(2):545-52. Epub 2005 Aug 3. Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target. Furutani T, Takeyama K, Tanabe M, Koutoku H, Ito S, Taniguchi N, Suzuki E, Kudoh M, Shibasaki M, Shikama H, Kato S.
- J Pharmacol Sci. 2005 Feb;97(2):184-9. Epub 2005 Feb 11. Nuclear receptors as targets for drug development: crosstalk between peroxisome proliferator-activated receptor gamma and cytokines in bone marrow-derived mesenchymal stem cells. Takada I, Suzawa M, Kato S.
- Genes Cells. 2004 Oct;9(10):983-92. In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation. Ito S, Takeyama K, Yamamoto A, Sawatsubashi S, Shirode Y, Kouzmenko A, Tabata T, Kato S.
- EMBO J. 2004 Apr 7;23(7):1598-608. Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. Murayama A, Kim MS, Yanagisawa J, Takeyama K, Kato S.
- Cell. 2003 Jun 27;113(7):905-17. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S.
- Nature. 2003 May 29;423(6939):545-50. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S.
- Nat Cell Biol. 2003 Mar;5(3):224-30. Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S.
- Mol Cell Biol. 2002 Jun;22(11):3698-706. Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex. Kitagawa H, Yanagisawa J, Fuse H, Ogawa S, Yogiashi Y, Okuno A, Nagasawa H, Nakajima T, Matsumoto T, Kato S.
- Nucleic Acids Res. 2002 Mar 15;30(6):1387-93. Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain. Matsui D, Sakari M, Sato T, Murayama A, Takada I, Kim M, Takeyama K, Kato S.
- Neuron. 2002 Aug 29;35(5):855-64. Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Takeyama K, Ito S, Yamamoto A, Tanimoto H, Furutani T, Kanuka H, Miura M, Tabata T, Kato S.
- EMBO J. 2001 Mar 15;20(6):1341-52. A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S.
- J Biol Chem. 1999 May 7;274(19):12971-4. Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins. Yanagi Y, Suzawa M, Kawabata M, Miyazono K, Yanagisawa J, Kato S.
- Biochem Biophys Res Commun. 1996 May 15;222(2):395-400. Retinoic acid differentially up-regulates the gene expression of retinoic acid receptor alpha and gamma isoforms in embryo and adult rats. Takeyama K, Kojima R, Ohashi R, Sato T, Mano H, Masushige S, Kato S.
- Biochem Biophys Res Commun. 2004 Jul 16;320(1):268-72. Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation. Sawatsubashi S, Maki A, Ito S, Shirode Y, Suzuki E, Zhao Y, Yamagata K, Kouzmenko A, Takeyama K, Kato S.
- Mol Cell Biol. 2009 Feb;29(4):1017-34. doi: 10.1128/MCB.02123-07. Epub 2008 Dec 15. Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Zhao Y, Takeyama K, Sawatsubashi S, Ito S, Suzuki E, Yamagata K, Tanabe M, Kimura S, Fujiyama S, Ueda T, Murata T, Matsukawa H, Shirode Y, Kouzmenko AP, Li F, Tabata T, Kato S.
- EMBO J. 2005 Nov 16;24(22):3881-94. Epub 2005 Oct 27. Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. Fujiki R, Kim MS, Sasaki Y, Yoshimura K, Kitagawa H, Kato S.
- Mol Cell Endocrinol. 2007 Feb;265-266:168-73. Epub 2007 Jan 23. 1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene. Kim MS, Fujiki R, Kitagawa H, Kato S.
- Genes Cells. 2008 Dec;13(12):1279-88. doi: 10.1111/j.1365-2443.2008.01244.x. Epub 2008 Nov 20. Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD. Tanabe M, Kouzmenko AP, Ito S, Sawatsubashi S, Suzuki E, Fujiyama S, Yamagata K, Zhao Y, Kimura S, Ueda T, Murata T, Matsukawa H, Takeyama K, Kato S.
- Mol Cell. 2002 Mar;9(3):553-62. Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Yanagisawa J, Kitagawa H, Yanagida M, Wada O, Ogawa S, Nakagomi M, Oishi H, Yamamoto Y, Nagasawa H, McMahon SB, Cole MD, Tora L, Takahashi N, Kato S.
- Endocrinology. 1999 May;140(5):2224-31. Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Murayama A, Takeyama K, Kitanaka S, Kodera Y, Kawaguchi Y, Hosoya T, Kato S.
- J Biol Chem. 2001 Nov 16;276(46):42684-91. Epub 2001 Sep 11. The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes. Yamamoto Y, Wada O, Suzawa M, Yogiashi Y, Yano T, Kato S, Yanagisawa J.
- Biochem Biophys Res Commun. 2002 Jun 21;294(4):779-84. Stabilization of androgen receptor protein is induced by agonist, not by antagonists. Furutani T, Watanabe T, Tanimoto K, Hashimoto T, Koutoku H, Kudoh M, Shimizu Y, Kato S, Shikama H.
- Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1673-8. Epub 2004 Jan 27. Brain masculinization requires androgen receptor function. Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K, Fukuda T, Aihara K, Krust A, Yamada T, Nakamichi Y, Yamamoto Y, Nakamura T, Yoshimura K, Yoshizawa T, Metzger D, Chambon P, Kato S.
- Oncogene. 2004 Aug 5;23(35):6000-5. BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S.
- Genes Cells. 2005 Dec;10(12):1095-102. Repressive domain of unliganded human estrogen receptor alpha associates with Hsc70. Ogawa S, Oishi H, Mezaki Y, Kouzu-Fujita M, Matsuyama R, Nakagomi M, Mori E, Murayama E, Nagasawa H, Kitagawa H, Yanagisawa J, Yano T, Kato S.
- EMBO J. 2007 Feb 7;26(3):764-74. Epub 2007 Jan 25. A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function. Takezawa S, Yokoyama A, Okada M, Fujiki R, Iriyama A, Yanagi Y, Ito H, Takada I, Kishimoto M, Miyajima A, Takeyama K, Umesono K, Kitagawa H, Kato S.
- Nature. 2007 Mar 29;446(7135):562-6. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, Takahashi S, Kouzmenko A, Nohara K, Chiba T, Fujii-Kuriyama Y, Kato S.
- Arch Biochem Biophys. 2007 Apr 15;460(2):166-71. Epub 2006 Aug 14. Multiple co-activator complexes support ligand-induced transactivation function of VDR. Yamaoka K, Shindo M, Iwasaki K, Yamaoka I, Yamamoto Y, Kitagawa H, Kato S.
- EMBO Rep. 2008 Jun;9(6):563-8. doi: 10.1038/embor.2008.55. Epub 2008 May 2. Switching of chromatin-remodelling complexes for oestrogen receptor-alpha. Okada M, Takezawa S, Mezaki Y, Yamaoka I, Takada I, Kitagawa H, Kato S.
- Nature. 2009 May 21;459(7245):455-9. doi: 10.1038/nature07954. Epub 2009 Apr 19. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Fujiki R, Chikanishi T, Hashiba W, Ito H, Takada I, Roeder RG, Kitagawa H, Kato S.
- Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9280-5. doi: 10.1073/pnas.0901184106. Epub 2009 May 26. Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Yoshimura K, Kitagawa H, Fujiki R, Tanabe M, Takezawa S, Takada I, Yamaoka I, Yonezawa M, Kondo T, Furutani Y, Yagi H, Yoshinaga S, Masuda T, Fukuda T, Yamamoto Y, Ebihara K, Li DY, Matsuoka R, Takeuchi JK, Matsumoto T, Kato S.
- J Biol Chem. 2010 Jun 11;285(24):18166-76. doi: 10.1074/jbc.M109.077024. Epub 2010 Apr 16. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. Matsuyama R, Takada I, Yokoyama A, Fujiyma-Nakamura S, Tsuji N, Kitagawa H, Fujiki R, Kim M, Kouzu-Fujita M, Yano T, Kato S.
- Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19891-6. doi: 10.1073/pnas.1010307107. Epub 2010 Nov 1. Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. Akimoto C, Ueda T, Inoue K, Yamaoka I, Sakari M, Obara W, Fujioka T, Nagahara A, Nonomura N, Tsutsumi S, Aburatani H, Miki T, Matsumoto T, Kitagawa H, Kato S.
- Cold Spring Harb Symp Quant Biol. 2011;76:165-73. doi: 10.1101/sqb.2011.76.010736. Epub 2011 Sep 2. Regulated histone methyltransferase and demethylase complexes in the control of genes by nuclear receptors. Yokoyama A, Fujiki R, Ohtake F, Kato S.
- Mol Cell. 2009 Oct 23;36(2):340-7. doi: 10.1016/j.molcel.2009.08.017. Maturation of microRNA is hormonally regulated by a nuclear receptor. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, Minami Y, O’Malley BW, Kato S.
- Mol Cell Biol. 1999 Aug;19(8):5363-72. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S.
- J Biol Chem. 2000 Oct 27;275(43):33201-4. Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S.
- Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):224-9. Epub 2005 Dec 22. Premature ovarian failure in androgen receptor-deficient mice. Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, Takemasa S, Sakari M, Takada I, Nakamura T, Metzger D, Chambon P, Kanno J, Yoshikawa H, Kato S.
- Nat Cell Biol. 2007 May;9(5):604-11. Epub 2007 Apr 15. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T, Akimoto C, Yamamoto Y, Katagiri T, Foulds C, Takezawa S, Kitagawa H, Takeyama K, O’Malley BW, Kato S.
- Biochem Biophys Res Commun. 2010 Apr 16;394(4):865-70. doi: 10.1016/j.bbrc.2010.02.167. Epub 2010 Mar 2. Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes. Chikanishi T, Fujiki R, Hashiba W, Sekine H, Yokoyama A, Kato S.